Lodine Capsules

Etodolac
300mg
JOHN WYETH & BROTHER LTD. TRADING AS WYETH LABORATORIES
Pack size 60's (6 x 10's Blister)
Dispensing mode POM
Source UK
AgentModern Pharmaceutical Co.
Retail Price 107.00 AED

Available as:

Indications

Lodine Capsules is used for: Rheumatoid arthritis, Pain, Osetoarthritis

Adult Dose

Oral Osteoarthritis; Rheumatoid arthritis Adult: 600-1000 mg/day in divided doses adjusted according to response. Max: 1200 mg/day. ER tablet: Once daily Hepatic impairment: Dose adjustment not necessary

Child Dose

Juvenile Rheumatoid Arthritis <6 years Safety and efficacy not established 6-16 years 20-30 kg (extended release): 400 mg PO once daily 31-45 kg (extended release): 600 mg PO once daily 46-60 kg (extended release): 800 mg PO once daily >60 kg (extended release): 1000 mg PO once daily

Renal Dose

Mild-to-moderate renal impairment: Dose adjustment not necessary Severe renal impairment; Not recommended

Administration

Should be taken with food. Take w/ or immediately after meals.

Contra Indications

Peptic ulcer, hypersensitivity to etodolac/NSAIDs. Childn; pregnancy (3rd trimester) and lactation.

Precautions

CHF, dehydration, impaired renal, hepatic function, history of GI disease. Elderly, patients receiving anticoagulant. Lactation: Unknown whether drug is excreted in breast milk; not recommended

Pregnancy-Lactation

Pregnancy category: C; avoid in late pregnancy (may cause premature closure of ductus arteriosus) Lactation: Unknown whether drug is excreted in breast milk; not recommended

Interactions

Increased effect of warfarin, lithium, methotrexate, digoxin, cyclosporin, aspirin. Effect may be reduced with aspirin. Reduced effect of some diuretics and ?-blockers. Alcohol enhances gastric mucosal irritation.

Adverse Effects

Side effects of Etodolac : 1-10% Dyspepsia (10%), Dizziness (3-9%), Nervousness (1-3%), Pruritus (1-3%), Blurred vision (1-3%), Depression (1-3%), Chills/fever (1-3%) >1% Asthenia, malaise, Blurred vision, Bronchospasm, Dysuria, urinary frequency, Edema, Melena, Rash, Tinnitus Potentially Fatal: Acute renal failure; blood disorder; nephrotoxicity; angioedema, arrhythmia, bone marrow suppression, CHF, dyspnoea, erythema multiforme, exfoliative dermatitis, hepatitis, hypertension, peripheral neuropathy, Stevens-Johnson syndrome, syncope, tachycardia, toxic amblyopia, toxic epidermal necrolysis, urticaria.

Mechanism of Action

Etodolac is an NSAID derived from pyrano-indoleacetic acid, inhibits cyclooxygenase 2 (COX-2) resulting in decreased prostaglandin precursor formation.

Note

Lodine 300mg Capsules manufactured by JOHN WYETH & BROTHER LTD. TRADING AS WYETH LABORATORIES. Its generic name is Etodolac. Lodine is availble in United Arab Emirates. Farmaco UAE drug index information on Lodine Capsules is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Etodolac :