Loflam Tablets
Aceclofenac
100mg
Medpharma Pharma. & Chem. Ind's (L.L.C)
| Pack size | 20's Plastic Bottle |
|---|---|
| Dispensing mode | POM |
| Source | UAE |
| Agent | Modern Pharmaceutical Co. |
| Retail Price | 44.00 AED |
Available as:
Indications
Loflam Tablets is used for:
Indicated for the relief of pain and inflammation in both acute and chronic pain like, osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, dental pain, post-traumatic pain, low back pain, gynaecological pain.
Adult Dose
Adult: PO Ankylosing spondylitis; Osteoarthritis; Rheumatoid arthritis
100 mg twice daily.
SR Tablet : The recommended dose is 200 mg, once daily.
Elderly: The pharmacokinetics of aceclofenac are not altered in elderly patients, therefore it is not considered necessary to modify the dose and dose frequency.
Hepatic Impairment Reduce initial dose to 100 mg daily .
Child Dose
Safety & Efficacy not established.
Renal Dose
No dose adjustment needed.
Administration
Should be taken with food. Take w/ or immediately after meals.
Contra Indications
Hypersensitivity to aspirin or NSAIDs; moderate to severe renal impairment; pregnancy (3rd trimester); history of peptic ulceration or GI bleed; patients with infections.
Precautions
Cautiously administer to patients with GI disease, ulcerative colitis, Crohn's disease, haematological abnormalities, hepatic porphyria; history of bronchial asthma; history of heart failure or hypertension; mild renal, hepatic or cardiac impairment. May impair ability to drive or operate machinery. Elderly. Patients suffering from severe hepatic impairment must be monitored.
Pregnancy-Lactation
USE IN PREGNANCY AND NURSING MOTHERS
Since there is no information on the safe use of Aceclofenac during pregnancy and lactation, the use of Aceclofenac should therefore be avoided in pregnancy and lactation.
Interactions
May increase plasma concentrations of lithium and digoxin. Increased nephrotoxicity when used with diuretics or ciclosporin. Monitor serum potassium when used with potassium-sparing diuretics and ACE inhibitors. May enhance activity of anticoagulants. May increase risk of methotrexate toxicity when administered within 24 hr of methotrexate admin. Increased risk of GI bleed with other NSAIDs. Increased risk of convulsion with quinolones.
Adverse Effects
Side effects of Aceclofenac :
Gastrointestinal disorders (dyspepsia, abdominal pain, nausea and diarrhoea) and occasional occurance of dizziness. Dermatological side effects including pruritus and rash. Abnormal hepatic enzyme levels and raised serum creatinine have occasionally been reported.
Potentially Fatal: Severe GI bleeding; nephrotoxicity; blood dyscrasias.
Mechanism of Action
Aceclofenac, a phenylacetic acid derivative, has antiinflammatory and analgesic properties. It is a potent inhibitor of cyclo-oxygenase which is involved in the production of prostaglandins.
Note
Loflam 100mg Tablets manufactured by Medpharma Pharma. & Chem. Ind's (L.L.C). Its generic name is Aceclofenac. Loflam is availble in United Arab Emirates.
Farmaco UAE drug index information on Loflam Tablets is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.