Lohist-Extra Syrup
Loratadine + Pseudoephedrine Hydrochloride
"5mg, 60mg/ml"
National Pharmaceutical industries Co. (SAOG)
| Pack size | 100ml Amber Glass Bottle |
|---|---|
| Dispensing mode | POM |
| Source | OMAN |
| Agent | NEW MEDICAL CENTRE |
| Retail Price | 13.50 AED |
Indications
Lohist-Extra Syrup is used for:
Allergic rhinitis, Nasal congestion
Adult Dose
Oral
Allergic Rhinitis/Nasal Congestion
Adult: (loratadine 5 mg and pseudoephedrine sulfate 120 mg): 1 tab twice daily.
(Loratadine 10 mg and pseudoephedrine sulfate 240 mg): 1 tab once daily.
Hepatic impairment: Severe: Initial dose of 1 tab (containing loratadine 5 mg and pseudoephedrine sulfate 120 mg) daily.
Child Dose
<12 years old
Safety & efficacy not established
Renal Dose
Administration
Contra Indications
Lactation. Narrow angle glaucoma, urinary retention, severe hypertension, severe coronary artery disease and hyperthyroidism. Patients on MAOI therapy or within 14 days of discontinuing MAOI.
Precautions
Glaucoma, increased intraocular pressure, stenosing peptic ulcer and pyloroduodenal obstruction, prostatic hypertrophy, bladder neck obstruction, CV disease, DM, severe liver impairment. Not recommended for use in pregnancy. Elderly.
Lactation: both drugs pass into breast milk, pseuoephedrine is concentrated in breast milk; use caution
Pregnancy-Lactation
Pregnancy Category: B
Lactation: both drugs pass into breast milk, pseuoephedrine is concentrated in breast milk; use caution
Interactions
Loratadine: Increased loratadine levels with ritonavir, amprenavir; increased loratadine levels with erythromycin, cimetidine and ketoconazole without evidence of clinical significance or toxicity; may block effects of betahistine.
Pseudoephedrine: Increased adverse effects (e.g. somnolence, agitation) with atomoxetine; increased BP or heart rate with sibutramine.
Potentially Fatal: Pseudoephedrine: Increased risk of psychosis with bromocriptine; increased risk of fatal hypertensive crisis with MAOI, avoid concurrent use during and for 2 wk after stopping the MAOI; increased BP with linezolid and selegiline.
Adverse Effects
Side effects of Loratadine + Pseudoephedrine Hydrochloride :
Insomnia, dry mouth, headache, nervousness, epistaxis, pharyngitis, dizziness, fatigue, tachycardia, postural hypotension, transient abnormal hepatic function, urinary retention, CNS stimulation, excitability.
Mechanism of Action
Loratadine is a long-acting, non-sedating antihistamine with little antimuscarinic activity. Pseudoephedrine, a vasoconstrictor, acts on the alpha-receptors and produces a decongestant effect by shrinking congested mucosa in the upper respiratory areas.
Note
Lohist-Extra "5mg, 60mg/ml" Syrup manufactured by National Pharmaceutical industries Co. (SAOG). Its generic name is Loratadine + Pseudoephedrine Hydrochloride. Lohist-Extra is availble in United Arab Emirates.
Farmaco UAE drug index information on Lohist-Extra Syrup is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.