Lomax Tablets
Lomefloxacin
400mg
Julphar (Gulf Pharmaceutical Industries)
| Pack size | 5's Blister |
|---|---|
| Dispensing mode | POM |
| Source | UAE |
| Agent | JULPHAR |
| Retail Price | 42.00 AED |
Available as:
Indications
Lomax Tablets is used for:
Chronic bronchitis, Otitis media, Bacterial Conjunctivitis, Urinary tract infections, Surgical Prophylaxis, Otitis externa
Adult Dose
Oral
Acute bacterial exacerbation of chronic bronchitis
Adult: 400 mg once daily for 10 days.
Uncomplicated urinary tract infections
Adult: 400 mg once daily.
Due to E. coli: For 3 successive days.
Due to K. pneumoniae, P. mirabilis or S. saprophyticus: For 10 successive days.
Complicated urinary tract infections
Adult: Due to E. coli, K. pneumoniae, P. mirabilis or P. aeruginosa: 400 mg once daily for 14 successive days.
Prophylaxis of surgical infections
Adult: 400 mg as a single dose 1-6 hr before procedure.
Child Dose
Renal Dose
Renal impairment: Haemodialysis: Initially, 400 mg daily. Maintenance: 200 mg daily.
CrCl (ml/min) Dosage Recommendation
10-40 Initially, 400 mg daily. Maintenance: 200 mg daily.
Administration
May be taken with or without food.
Contra Indications
Hypersensitivity to the drug or other quinolones; children <18 yr; pregnancy and lactation.
Precautions
Avoid prolonged exposure to sunlight or artificial UV light. Known or suspected CNS disorders e.g. severe cerebral arteriosclerosis, epilepsy or other factors that predispose to seizures. Avoid in patients with known QT prolongation, uncorrected hypokalaemia. May impair ability to drive or operate machinery. Renal impairment.
Pregnancy-Lactation
Interactions
Reduced bioavailability with sucralfate, antacids containing magnesium or aluminium, vitamin or mineral supplements containing iron. Increased serum levels with cimetidine. Potential increase in serum levels of ciclosporin. Renal elimination reduced with probenecid.
Potentially Fatal: Increased risk of ventricular arrhythmias with class IA (quinidine, procainamide) or class III (amiodarone, sotalol) antiarrhythmic agents.
Adverse Effects
Side effects of Lomefloxacin :
Nausea, abdominal pain or discomfort, diarrhoea; headache, dizziness, insomnia; rash, pruritus, photosensitivity; thrombocytopenia.
Potentially Fatal: Anaphylactic or anaphylactoid reactions.
Mechanism of Action
Lomefloxacin promotes breakage of double-stranded DNA in susceptible organisms and inhibits DNA gyrase, which is essential in reproduction of bacterial DNA.
Note
Lomax 400mg Tablets manufactured by Julphar (Gulf Pharmaceutical Industries). Its generic name is Lomefloxacin. Lomax is availble in United Arab Emirates.
Farmaco UAE drug index information on Lomax Tablets is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.