Lopid Tablets / Film-coated

Gemfibrozil
600mg
PARKE DAVIS & CO.
Pack size 30's (10's Blister x 3)
Dispensing mode POM
Source GERMANY
AgentNEW MEDICAL CENTRE
Retail Price 52.00 AED

Indications

Lopid Tablets / Film-coated is used for: Hypertriglyceridemia, Hyperlipidemia

Adult Dose

Hypertriglyceridemia, Hypercholesterolemia 600 mg PO q12hr Hepatic impairment Contraindicated

Child Dose

Safety and efficacy not established

Renal Dose

Renal impairment Mild to moderate: Use caution, if baseline serum creatine in patient is >2mg/dL; deterioration of renal function reported in such patients Severe: Contraindicated

Administration

Should be taken on an empty stomach. Take ½ hr before meals.

Contra Indications

Hypersensitivity. Severe hepatic or renal dysfunction; gall stones; neonates, children, pregnancy, lactation.

Precautions

Causes of secondary hyperlipidaemia such as hypothyroidism and diabetes must be treated before initiating therapy. Renal impairment; blood disorders. Periodic monitoring of the serum lipids should be done; if no adequate response after 3 mth, treatment should be withdrawn. May increase risk of cholelithiasis. Lactation: Not recommended

Pregnancy-Lactation

Pregnancy category: C Lactation: Not recommended

Interactions

Co-admin with repaglinide may increase serum levels of repaglinide. May enhance effects of oral anticoagulants. May also increase the plasma concentrations of ciclosporin and associated nephrotoxicity when used concurrently. Potentially Fatal: Increased risk of myopathy and rhabdomyolysis when used with HMG-CoA reductase inhibitors.

Adverse Effects

Side effects of Gemfibrozil : >10% Dyspepsia (20%) 1-10% Abdominal pain (10%), Atrial fibrillation (1%), Diarrhea (7%), Fatigue (4%), N/V (3%), Eczema (2%), Rash (2%), Vertigo (2%), Constipation (1%), Headache (1%) <1% Myalgia, Rhabdomyolysis (especially with admin with statin), Acute appendicitis, Cholelithiasis, Angioedema, Hypokalemia, Eosinophilia, Myopathy, Synovitis, Taste disturbance, Xerostomia, Flatulence, Rash Potentially Fatal: Bone marrow hypoplasia; intracranial haemorrhage; nephrotoxicity; peripheral neuritis.

Mechanism of Action

Gemfibrozil exhibits its action by inhibition of lipolysis and reduction of hepatic fatty acid uptake. It also inhibits secretion of VLDL from the liver.

Note

Lopid 600mg Tablets / Film-coated manufactured by PARKE DAVIS & CO.. Its generic name is Gemfibrozil. Lopid is availble in United Arab Emirates. Farmaco UAE drug index information on Lopid Tablets / Film-coated is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Gemfibrozil :