Lysthenon Siccum Infusion
Suxamethonium Chloride (Succinylcholine)
500mg
NYCOMED AUSTRIA GmbH
| Pack size | 10 Vials (Powder) |
|---|---|
| Dispensing mode | POM |
| Source | AUSTRIA |
| Agent | PHARMAWORLD |
| Retail Price | 132.00 AED |
Indications
Lysthenon Siccum Infusion is used for:
Muscle relaxant
Adult Dose
Intravenous
Muscle relaxant in general anaesthesia
Adult: As suxamethonium Cl: Single dose of 0.3-1.1 mg/kg by inj. Supplementary doses of 50-100% of the initial dose may be given at 5-10 min intervals.
For prolonged procedures, 0.1-0.2% soln by infusion at 2.5-4 mg/min, adjusted as necessary. Max (repeated inj or continuous infusion): 500 mg/hr.
Intramuscular
Muscle relaxant in general anaesthesia
Adult: As suxamethonium Cl: 3-4 mg/kg. Max: 150 mg.
Child Dose
Intravenous
Muscle relaxant in general anaesthesia
Child: As suxamethonium Cl: <1 yr 2 mg/kg; 1-12 yr 1 mg/kg.
Intramuscular
Muscle relaxant in general anaesthesia
Child: As suxamethonium Cl: <1 yr Up to 5 mg/kg;
>1 yr Up to 4 mg/kg. Max: 150 mg.
Renal Dose
Administration
Reconstitution: IV infusion: Suxamethonium Cl 1 g powd for inj or 20 mL of a soln containing 50 mg/mL may be added to 1,000 mL or 500 mL of diluent (e.g. dextrose 5%, dextrose 5% and NaCl 0.9%, NaCl 0.9%, or (1/6) M Na lactate inj) to provide a soln containing 1 mg/mL (0.1%) or 2 mg/mL (0.2%), respectively. Alternatively, suxamethonium Cl 500 mg powd for inj or 10 mL of a soln containing 50 mg/mL may be added to 500 mL or 250 mL of diluents to provide a soln containing 1 mg/mL (0.1%) or 2 mg/mL (0.2%), respectively.
Contra Indications
Genetic disorders of plasma pseudocholinesterase, personal/family history of malignant hyperthermia, hypersensitivity from previous neuromuscular drug, severe burns, massive trauma, extensive denervation of skeletal muscle, patients with risk of hyperkalaemia, renal impairment, angle closure glaucoma.
Precautions
Hypersensitivity to any neuromuscular blocker. Patient w/ reduced plasma cholinesterase activity, bone fractures, neuromuscular disorders, cardiac or resp disease, electrolyte imbalance, suspected cardiac glycoside toxicity. Childn. Pregnancy and lactation. Monitoring Parameters Monitor cardiac function and oxygenation during admin; temp, serum K and Ca, assisted ventilator status; neuromuscular function w/ peripheral nerve stimulator.
Pregnancy-Lactation
Pregnancy
Not known whether succinylcholine can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity; animal reproduction studies not conducted with succinylcholine chloride; therapy should be administered to a pregnant woman only if clearly needed
Labor and delivery
Drug is commonly used to provide muscle relaxation during delivery by Cesarean section; while small amounts of succinylcholine are known to cross placental barrier, under normal conditions the quantity of drug that enters fetal circulation after a single dose of 1 mg/kg to mother should not endanger fetus; however, since amount of drug that crosses the placental barrier is dependent on concentration gradient between maternal and fetal circulations, residual neuromuscular blockade (apnea and flaccidity) may occur in the neonate after repeated high doses to, or in the presence of atypical plasma cholinesterase in, the mother
Lactation
Not known whether drug excreted in human milk; because many drugs are excreted in human milk, use caution following succinylcholine administration to a nursing woman
Interactions
Prolonged neuromuscular blocking effects w/ specific anticholinesterase agents (e.g. neostigmine), cytotoxic compd (e.g. cyclophosphamide), antiarrhythmics (e.g. quinidine), aminoglycosides, psychiatric drugs (e.g. chlorpromazine), Mg salts, anaesth agents (e.g. morphine), SSRIs, organophosphate insecticides. Increased susceptibility to the effects of suxamethonium-exacerbated hyperkalaemia w/ digitalis-like drugs.
Adverse Effects
Side effects of Suxamethonium Chloride (Succinylcholine) :
Prolonged resp depression or apnoea, bradycardia, tachycardia, hypotension, HTN, raised intraocular pressure, hyperkalaemia, muscle fasciculation, excessive salivation, jaw rigidity, rash.
Potentially Fatal: Anaphylactic and anaphylactoid reactions, acute rhabdomyolysis w/ hyperkalaemia followed by ventricular dysrhythmias and cardiac arrest, malignant hyperthermia.
Mechanism of Action
Suxamethonium chloride is an ultrashort-acting depolarising type skeletal muscle relaxant. It blocks the neuromuscular junction by binding to the cholinergic receptors and depolarising it.
Note
Lysthenon Siccum 500mg Infusion manufactured by NYCOMED AUSTRIA GmbH. Its generic name is Suxamethonium Chloride (Succinylcholine). Lysthenon Siccum is availble in United Arab Emirates.
Farmaco UAE drug index information on Lysthenon Siccum Infusion is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.