Medacin T 1% Topical Solution
Clindamycin 1% Topical
10mg/ml
Medpharma Pharma. & Chem. Ind's (L.L.C)
| Pack size | 30ml Plastic Dropper Bottle |
|---|---|
| Dispensing mode | POM |
| Source | UAE |
| Agent | Modern Pharmaceutical Co. |
| Retail Price | 23.50 AED |
Available as:
Indications
Medacin T 1% Topical Solution is used for:
Acne vulgaris, erythrasma, rosacea, periorificial dermatitis, folliculitis, stasis, chronic lymphaedema and familial pemphigus, dermal ulcers.
Adult Dose
Topical/Cutaneous
Acne
Adult: As 1% preparation: Apply a thin layer onto affected area bid.
Child Dose
<12 years old
Safety and efficacy not established
>12 years: Apply a thin layer onto affected area bid.
Renal Dose
Administration
Contra Indications
Contraindicated in patients with hypersensitivity to clindamycin.
Precautions
It is not for oral, ophthalmic, or Intravaginal use.
Avoid exposure to sunlight and sunlamps. Wear sunscreen daily.
Lactation: Excretion in milk unknown; use with caution
Pregnancy-Lactation
Pregnancy
In clinical trials with pregnant women, systemic administration of clindamycin during second and third trimesters has not been associated with increased frequency of congenital abnormalities; there are no adequate studies in pregnant women during first trimester of pregnancy; clindamycin should be used during first trimester of pregnancy only if clearly needed
Lactation
Not known whether clindamycin is excreted in human milk following therapy; however, orally and parenterally administered clindamycin has been reported to appear in breast milk; clindamycin has potential to cause adverse effects on breastfed infant's gastrointestinal flora; if oral or intravenous clindamycin is required by a nursing mother, it is not a reason to discontinue breastfeeding, but an alternate drug may be preferred; monitor infant for possible adverse effects on gastrointestinal flora, such as diarrhea, candidiasis (thrush, diaper rash) or rarely, blood in the stool indicating possible antibiotic-associated colitis
Developmental and health benefits of breastfeeding should be considered along with mother's clinical need for clindamycin and any potential adverse effects on breastfed child from clindamycin or from underlying maternal condition
Interactions
May enhance the action of neuromuscular blocking agents (e.g. atracurium). May antagonise the effects of parasympathomimetics. May competitively inhibit the effects of macrolides, ketolides, streptogramins, linezolid and chloramphenicol. Increased coagulation tests (prothrombin time/INR) and/or bleeding w/ vit K antagonists (e.g. warfarin, acenocoumarol, fluindione).
Adverse Effects
Side effects of Clindamycin 1% Topical :
>10%
Dryness (18-23%), Oiliness (1-18%), Erythema (7-16%), Peeling (7-11%), Burning/itching (6-11%)
1-10%
Headache (3%)
Mechanism of Action
Clindamycin inhibits protein synthesis by reversibly binding to the 50S subunit of the ribosomal thus blocking the transpeptidation or translocation reactions of susceptible organisms resulting to stunted cell growth.
Note
Medacin T 1% 10mg/ml Topical Solution manufactured by Medpharma Pharma. & Chem. Ind's (L.L.C). Its generic name is Clindamycin 1% Topical. Medacin T 1% is availble in United Arab Emirates.
Farmaco UAE drug index information on Medacin T 1% Topical Solution is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.
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