MERIONAL Infusion
Human Menopausal Gonadotrophin
150 IU
IBSA INSTITUT BIOCHIMIQUE S.A.
| Pack size | 1 Vial (Lyophilized Powder) + 1 Solvent Ampoule |
|---|---|
| Dispensing mode | POM |
| Source | SWITZERLAND |
| Agent | GULF DRUG EST. |
| Retail Price | 113.00 AED |
Available as:
Indications
MERIONAL Infusion is used for:
Female infertility, Male infertility, In vitro fertilisation procedures or other assisted conception techniques
Adult Dose
Parenteral
Female infertility
Adult: 75-150 units of FSH daily via IM or SC inj; adjust gradually until adequate response is achieved. Treatment is stopped and followed after 1 or 2 days by single dose of chorionic gonadotrophin 5000-10,000 units.
In menstruating patients, start within the 1st 7 days of menstrual cycle. Alternatively, 3 equal doses IM or SC, each providing 225-375 units of FSH on alternate days followed by chorionic gonadotrophin 1 wk after the 1st dose. Stop treatment if no response is seen in 3 wk. Course may be repeated twice more, if necessary.
Male infertility
Adult: Stimulate spermatogenesis with chorionic gonadotrophin, then with human menopausal gonadotrophin in a dose of 75 or 150 units of FSH 2 or 3 times wkly by IM or SC. Treatment should be continued for at least 3 or 4 mth.
In vitro fertilisation procedures or other assisted conception techniques
Adult: (In conjunction with chorionic gonadotrophin and sometimes clomiphene citrate or a gonadorelin analogue.) 75-300 units of FSH daily via IM or SC inj usually beginning on the 2nd or 3rd day of menstrual cycle.
Combined regimen: 100 mg clomiphene citrate on days 2-6, with human menopausal gonadotrophins beginning on day 5 in a dose providing 150-225 units of FSH daily. Continue until an adequate response is obtained; final inj of human menopausal gonadotrophins is followed 1-2 days later with up to 10,000 units of chorionic gonadotrophin.
Child Dose
Renal Dose
Administration
Contra Indications
Ovarian cysts or enlargement not caused by polycystic ovarian syndrome; tumors of breast, uterus, ovaries, testes or prostate; vaginal bleeding of unknown cause; pregnancy and lactation.
Precautions
Hyperprolactinemia or tumors of the pituitary or hypothalamus. Ovarian enlargement at risk of rupture, care in pelvic examinations. Risk of multiple births.
Pregnancy-Lactation
Interactions
Drugs with luteinising hormone activity may increase risk of ovarian hyperstimulation syndrome.
Adverse Effects
Side effects of Human Menopausal Gonadotrophin :
Ovarian hyperstimulation, risk of multiple pregnancy and miscarriage, hypersensitivity and local reactions at Inj site, nausea, vomiting, joint pain, fever. In men, gynecomastia, acne, weight gain.
Potentially Fatal: Rupture of ovarian cysts and intraperitoneal haemorrhage.
Mechanism of Action
Human menopausal gonadotrophins possess both follicle-stimulating hormone (FSH) and luteinizing hormone (LH) activities.
Note
MERIONAL 150 IU Infusion manufactured by IBSA INSTITUT BIOCHIMIQUE S.A.. Its generic name is Human Menopausal Gonadotrophin. MERIONAL is availble in United Arab Emirates.
Farmaco UAE drug index information on MERIONAL Infusion is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.