Methyldopa Tablets
Methyldopa
250mg
C.P.PHARMACEUTICALS
| Pack size | 500's |
|---|---|
| Dispensing mode | POM |
| Source | UK |
| Agent | AL RAZI PHARMACY |
| Retail Price | 113.00 AED |
Indications
Methyldopa Tablets is used for:
Hypertension
Adult Dose
Oral
Hypertension
Adult: Monotherapy: Initially, 250 mg bid-tid for 2 days; adjust at intervals of at least 2 days according to response. Maintenance: 500-2,000 mg daily.
Max: 3,000 mg daily. Combination therapy: Initial dose should not exceed 500 mg daily in divided doses.
Elderly: Initially, 125 mg bid; gradually increase according to response. Max: 2,000 mg daily.
Child Dose
Oral
Hypertension
Child: <12 yr Initially, 10 mg/kg or 300 mg/m2 daily in 2-4 divided doses; adjust at intervals of at least 2 days according to response.
Max: 65 mg/kg, 2,000 mg/m2 or 3,000 mg daily, whichever is least.
Renal Dose
Renal Impairment
Adjust dosage frequency with renal impairment
CrCl >50 mL/min: q8hr
CrCl 10-50 mL/min: q8-12hr
CrCl <10 mL/min: q12-24hr
Administration
May be taken with or without food.
Contra Indications
Active liver disease (e.g. acute hepatitis, active cirrhosis) or depression. Concomitant use w/ MAOIs.
Precautions
Patient w/ history of haemolytic anaemia, liver disease or depression; parkinsonism, hepatic porphyria. Not intended for the treatment of phaeochromocytoma. Renal or hepatic impairment. Childn, elderly. Pregnancy and lactation. Patient Counselling May impair ability to drive or operate machinery. Monitoring Parameters Monitor BP, blood counts, liver enzymes; direct Coombs' test.
Lactation: distributed in breast milk but not in clinically significant amounts; compatible w/ breastfeeding
Pregnancy-Lactation
Pregnancy Category: B
Lactation: distributed in breast milk but not in clinically significant amounts; compatible w/ breastfeeding
Interactions
Reduced hypotensive effects with phenothiazines, TCAs and possibly, amphetamines. Additive hypotensive effects with levodopa; psychosis may also occur. Reduced absorption and effects with oral iron preparations. Reduced doses of general anaesthetics may be required. Effect of ephedrine may be reduced.
Potentially Fatal: Increased risk of severe hypertension with MAOIs. Increased lithium toxicity
Adverse Effects
Side effects of Methyldopa :
Drowsiness, orthostatic hypotension, nausea, headache, weakness, fatigue, decreased libido, impotence, impaired concentration and memory, mild psychoses, depression, disturbed sleep, nightmares, paraesthesias, Bell's palsy, parkinsonism, involuntary choreoathetotic movements, oedema, fluid retention, exacerbation of angina pectoris, bradycardia, syncope, prolonged carotid sinus hypersensitivity, paradoxical HTN, GI disturbances (e.g. nausea, vomiting, diarrhoea, constipation), black/sore tongue, inflamed salivary glands, dry mouth, fever, eosinophilia, liver function disturbances, hepatitis, lupus-like syndrome, rashes, lichenoid and granulomatous eruptions, toxic epidermal necrolysis, flu-like syndrome, nocturia, uraemia, nasal congestion, retroperitoneal fibrosis, hyperprolactinaemia, breast enlargement (including gynaecomastia), galactorrhoea, amenorrhoea.
Rarely, pancreatitis and colitis, immune thrombocytopenia, reversible leucopenia (primarily granulocytopenia).
Potentially Fatal: Hepatic necrosis, haemolytic anaemia, hypersensitivity myocarditis.
Mechanism of Action
Methyldopa stimulates alpha 2-adrenoceptors which results in reduced sympathetic tone and fall in BP.
Note
Methyldopa 250mg Tablets manufactured by C.P.PHARMACEUTICALS. Its generic name is Methyldopa. Methyldopa is availble in United Arab Emirates.
Farmaco UAE drug index information on Methyldopa Tablets is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.