Mevacor Tablets
Lovastatin
20mg
MERCK SHARP & DOHME DE ESPANA, S.A.E.
| Pack size | 56's (7's Blister x 8) |
|---|---|
| Dispensing mode | POM |
| Source | SPAIN |
| Agent | CITY MEDICAL STORE |
| Retail Price | 342.50 AED |
Available as:
Indications
Mevacor Tablets is used for:
Coronary Artery Disease, Hyperlipidaemias
Adult Dose
Oral
Hyperlipidaemias; Primary prophylaxis of coronary artery disease
Adult: Initially, 10-20 mg/day in the evening, may increase at intervals of at least 4 wk to max 80 mg/day as a single or in 2 divided doses.
Child Dose
Oral
Hyperlipidaemias; Primary prophylaxis of coronary artery disease
Child: As an adjunct w/ heterozygous familial hypercholesterolaemia: 10-17 yr Initially, 10-20 mg once daily, may increase at intervals of 4 wk to max 40 mg once daily.
Renal Dose
Renal impairment:
CrCl (ml/min) Dosage Recommendation
<30 Use w/ caution in doses >20 mg/day.
Administration
Should be taken with food.
Contra Indications
Active liver disease or unexplained persistent elevated serum transaminases. Concomitant use w/ CYP3A4 inhibitors (e.g. nefazodone, erythromycin, boceprevir, clarithromycin, telithromycin, HIV protease inhibitors, itraconazole, ketoconazole, posaconazole, telaprevir), gemfibrozil, ciclosporin. Pregnancy and lactation.
Precautions
History of liver disease; patients at risk of myopathy; alcoholism; inadequately controlled hypothyroidism. Severe renal impairment. Monitoring Parameters Monitor creatine kinase (CK) periodically and LFT. Discontinue if there is significant or persistent increase in CK levels, serum aminotransferase levels or evidence of myopathy.
Lactation: Contraindicated; unsafe
Pregnancy-Lactation
Pregnancy category: X
Lactation: Contraindicated; unsafe
Interactions
Increased risk of myopathy/rhabdomyolysis w/ amiodarone, colchicine, ranolazine, danazol, diltiazem and verapamil. May increase anticoagulant effect of warfarin.
Potentially Fatal: Increased risk of myopathy and rhabdomyolysis w/ concomitant CYP3A4 inhibitors (e.g. nefazodone, erythromycin, boceprevir, clarithromycin, telithromycin, HIV protease inhibitors, itraconazole, ketoconazole, posaconazole, telaprevir), gemfibrozil, ciclosporin.
Adverse Effects
Side effects of Lovastatin :
>10%
CPK elevation (11%)
1-10%
Flatulence (4-5%), Abdominal pain (2-3%), Constipation (2-3%), Diarrhea (2-3%), Myalgia (2-3%), Nausea (2-3%), Dyspepsia (1-2%), Weakness (1-2%), Blurred vision (0.8-1%), Rash (0.8-1%), Muscle cramps (0.6-1%), Dizziness (0.5-1%)
<1%
Dermatomyositis, Increased LFTs, Hepatotoxicity, Myopathy, Rhabdomyolysis
Potentially Fatal: Rhabdomyolysis and acute renal failure.
Mechanism of Action
Lovastatin reduces cholesterol by competitively inhibiting HMG-CoA reductase, the rate-limiting step cholesterol biosynthesis.
Note
Mevacor 20mg Tablets manufactured by MERCK SHARP & DOHME DE ESPANA, S.A.E.. Its generic name is Lovastatin. Mevacor is availble in United Arab Emirates.
Farmaco UAE drug index information on Mevacor Tablets is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.