Micardis Plus 40/12.5mg Tablets

Telmisartan, Hydrochlorothiazide
"40mg, 12.5mg"
Boehringer Ingelheim GmbH
Pack size 28's (7's Blister x 4)
Dispensing mode POM
Source GERMANY
AgentGULF DRUG EST.
Retail Price 106.50 AED

Indications

Micardis Plus 40/12.5mg Tablets is used for: TELMISARTAN
Used alone or in combination with other classes of antihypertensives for the treatment of hypertension. Also used in the treatment of diabetic nephropathy in hypertensive patients with type 2 diabetes mellitus, as well as the treatment of congestive heart failure (only in patients who cannot tolerate ace inhibitors)
HYDROCHLOROTHIAZIDE
For the treatment of high blood pressure and management of edema

Adult Dose

Child Dose

Renal Dose

Administration

Contra Indications

Precautions

Pregnancy-Lactation

Interactions

Adverse Effects

Side effects of Telmisartan, Hydrochlorothiazide :

Mechanism of Action

TELMISARTAN
Telmisartan interferes with the binding of angiotensin ii to the angiotensin ii at1-receptor by binding reversibly and selectively to the receptors in vascular smooth muscle and the adrenal gland. As angiotensin ii is a vasoconstrictor, which also stimulates the synthesis and release of aldosterone, blockage of its effects results in decreases in systemic vascular resistance. Telmisartan does not inhibit the angiotensin converting enzyme, other hormone receptors, or ion channels. Studies also suggest that telmisartan is a partial agonist of pparγ, which is an established target for antidiabetic drugs. This suggests that telmisartan can improve carbohydrate and lipid metabolism, as well as control insulin resistance without causing the side effects that are associated with full pparγ activators
HYDROCHLOROTHIAZIDE
Hydrochlorothiazide, a thiazide diuretic, inhibits water reabsorption in the nephron by inhibiting the sodium-chloride symporter (slc12a3) in the distal convoluted tubule, which is responsible for 5% of total sodium reabsorption. Normally, the sodium-chloride symporter transports sodium and chloride from the lumen into the epithelial cell lining the distal convoluted tubule. The energy for this is provided by a sodium gradient established by sodium-potassium atpases on the basolateral membrane. Once sodium has entered the cell, it is transported out into the basolateral interstitium via the sodium-potassium atpase, causing an increase in the osmolarity of the interstitium, thereby establishing an osmotic gradient for water reabsorption. By blocking the sodium-chloride symporter, hydrochlorothiazide effectively reduces the osmotic gradient and water reabsorption throughout the nephron

Note

Micardis Plus 40/12.5mg "40mg, 12.5mg" Tablets manufactured by Boehringer Ingelheim GmbH. Its generic name is Telmisartan, Hydrochlorothiazide. Micardis Plus 40/12.5mg is availble in United Arab Emirates. Farmaco UAE drug index information on Micardis Plus 40/12.5mg Tablets is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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