Mododom Tablets / Film-coated

Domperidone
10mg
Julphar (Gulf Pharmaceutical Industries)
Pack size 20's Blister
Dispensing mode POM
Source UAE
AgentJULPHAR
Retail Price 12.00 AED

Available as:

1mg/ml - Suspension

Indications

Mododom Tablets / Film-coated is used for: Gastritis, Lactation, Migraine, Nausea and vomiting, Gastroparesis, Non ulcer dyspepsia

Adult Dose

Oral Adults: Nausea and vomiting 10-20 mg 4-8 hrly. Max: 80 mg/day. Non ulcer dyspepsia 10 mg 3-4 times daily. Max: 20 mg 3-4 times daily. Last dose to be taken at bedtime. Migraine 20 mg 4 hrly. Max: 4 doses/24 hr. Rectal: Nausea and vomiting 60 mg twice daily. Elderly: No dosage adjustment needed. Hepatic impairment: No dosage adjustment needed.

Child Dose

Oral Children : 0.2 - 0.4 mg/kg every 4 - 8 hours daily. Rectal Child: <12 yr >15 kg: 30 mg bid; >12 yr >35 kg: 60 mg bid.

Renal Dose

Renal impairment: Mild to moderate: No dosage adjustment needed. Severe: Reduce dosing to 1-2 times daily w/ prolonged treatment.

Administration

Should be taken on an empty stomach. Take 15-30 min before meals.

Contra Indications

Hypersensitivity. GI haemorrhage, obstruction and perforation, patients with prolactin releasing pituitary hormone, chronic admin or routine prophylaxis of postoperative nausea and vomiting.

Precautions

Phaeochromocytoma; children<2 yr, elderly; renal or hepatic impairment. Risk of cardiac arrhythmias and hypokalaemia if administered IV. Pregnancy and lactation.

Pregnancy-Lactation

Interactions

May antagonise the hypoprolactinaemic effect of bromocriptine. May antagonise the prokinetic effect w/ opioid analgesics and antimuscarinics. Potentially Fatal: Potent CYP3A4 inhibitors (e.g. ketoconazole, erythromycin or ritonavir) may increase serum domperidone levels and subsequently increasing the risk of QT prolongation.

Adverse Effects

Side effects of Domperidone : Drowsiness, extrapyramidal reactions, galactorrhoea, gynaecomastia; constipation or diarrhoea, lassitude, decreased libido, skin rash, itch. Potentially Fatal: Convulsions, arrhythmias and cardiac arrest, dysrrhythmias in patients with CV disease or hypokalaemia, patients on cancer chemotherapy. Seizures; hypertensive crisis in patients with phaeochromocytoma.

Mechanism of Action

Domperidone is a peripheral dopamine-receptor blocker. It increases oesophageal peristalsis, enhances gastroduodenal coordination and lowers oesophageal sphincter pressure, gastric motility and peristalsis, thus facilitating gastric emptying and decreasing small bowel transit time.

Note

Mododom 10mg Tablets / Film-coated manufactured by Julphar (Gulf Pharmaceutical Industries). Its generic name is Domperidone. Mododom is availble in United Arab Emirates. Farmaco UAE drug index information on Mododom Tablets / Film-coated is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Domperidone :

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Mododom 1mg/ml
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