MONOTRIM Suspension

Trimethoprim
Not available
GEA LTD.
Pack size 100ml
Dispensing mode POM
Source DENMARK
AgentMETROPOLITAN MEDICAL MARKETING
Retail Price 11.00 AED

Indications

MONOTRIM Suspension is used for: Urinary tract infections, Gastroenteritis, Pneumocystis jiroveci pneumonia, Resp tract infections

Adult Dose

Oral Respiratory tract infections; Gastroenteritis; Susceptible infections; Uncomplicated urinary tract infections Adult: Acute infection: 100 or 200 mg twice daily, alternatively, 200 or 300 mg daily as a single dose may be used. For initial UTI episodes: 100 mg every 12 hr or 200 mg every 24 hr for 10 days. Intravenous Respiratory tract infections; Gastroenteritis; Treatment and prophylaxis of urinary tract infections Adult: 200 mg every 12 hr by Inj or infusion.

Child Dose

Oral Respiratory tract infections; Gastroenteritis; Susceptible infections; Uncomplicated urinary tract infections Child: 6-8 mg/kg/day in 2 divided doses. Alternatively, 6 wk-5 mth: 25 mg bid, 6 mth-5 yr: 50 mg bid, 6-12 yr: 100 mg bid. Intravenous Respiratory tract infections; Gastroenteritis; Treatment and prophylaxis of urinary tract infections Child: 8 mg/kg daily in 2-3 divided doses.

Renal Dose

Renal impairment: CrCl (ml/min) Dosage Recommendation 15-27 Normal dose for 3 days, thereafter half the normal doses. <15 Half the normal dose from the start of the treatment.

Administration

Should be taken with food.

Contra Indications

Hypersensitivity, serious haematological disorders, severe renal impairment, megaloblastic anaemia secondary to folate depletion.

Precautions

Renal and hepatic impairment, porphyria, patients with potential folate deficiency, elderly, pregnancy, lactation, children with fragile X chromosome associated with mental retardation. Perform regular haematological examination.

Pregnancy-Lactation

Pregnancy Category: C Lactation: enters breast milk

Interactions

Concurrent use increased risk of blood dyscrasias with azathioprine, methotrexate, pyrimethamine; increased risk of hyperkalaemia with ACE inhibitors; increased risk of hyponatraemia when used with both potassium-sparing diuretics and thiazides; increased risk of bleeding with warfarin; increased risk of lithium toxicity; increased digoxin, phenytoin, procainamide, lamivudine, stavudine, repaglinide, rosiglitazone, dofetilide serum levels; decreased ciclosporin levels. Concurrent use with dapsone increased serum levels of both and increased risk of dapsone toxicity.

Adverse Effects

Side effects of Trimethoprim : Nausea, vomiting, glossitis, pruritus, skin rash, fever, hyponatremia, hyperkalaemia, photosensitivity, liver enzyme elevation, , raised serum creatinine and BUN, blood dyscrasias, cholestatic jaundice, anaphylaxis, aseptic meningitis. Potentially Fatal: Stevens-Johnson syndrome, toxic epidermal necrolysis.

Mechanism of Action

Trimethoprim inhibits the conversion of bacterial dihydrofolic acid to tetrahydrofolic acid which is important for the synthesis of DNA. It may be bacteriostatic or bactericidal depending on growth conditions. It is active against a wide range of gm-ve and gm+ve aerobes, as well as some protozoa.

Note

MONOTRIM Not available Suspension manufactured by GEA LTD.. Its generic name is Trimethoprim. MONOTRIM is availble in United Arab Emirates. Farmaco UAE drug index information on MONOTRIM Suspension is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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