Mynah 250 Tablets
Ethambutol, Isoniazid
"250mg, 100mg"
LEDERLE LAB (DIV.CYANAMIDE CO. GREAT BRITAIN)
| Pack size | 84's |
|---|---|
| Dispensing mode | POM |
| Source | UK |
| Agent | PHARMATRADE |
| Retail Price | 86.50 AED |
Available as:
Indications
Mynah 250 Tablets is used for:
ETHAMBUTOL
For use, as an adjunct, in the treatment of pulmonary tuberculosis
ISONIAZID
For the treatment of all forms of tuberculosis in which organisms are susceptible
For use, as an adjunct, in the treatment of pulmonary tuberculosis
ISONIAZID
For the treatment of all forms of tuberculosis in which organisms are susceptible
Adult Dose
Child Dose
Renal Dose
Administration
Contra Indications
Precautions
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Ethambutol, Isoniazid :
Mechanism of Action
ETHAMBUTOL
Ethambutol inhibits arabinosyl transferases which is involved in cell wall biosynthesis. By inhibiting this enzyme, the bacterial cell wall complex production is inhibited. This leads to an increase in cell wall permeability
ISONIAZID
Isoniazid is a prodrug and must be activated by bacterial catalase. Specficially, activation is associated with reduction of the mycobacterial ferric katg catalase-peroxidase by hydrazine and reaction with oxygen to form an oxyferrous enzyme complex. Once activated, isoniazid inhibits the synthesis of mycoloic acids, an essential component of the bacterial cell wall. At therapeutic levels isoniazid is bacteriocidal against actively growing intracellular and extracellular mycobacterium tuberculosis organisms. Specifically isoniazid inhibits inha, the enoyl reductase from mycobacterium tuberculosis, by forming a covalent adduct with the nad cofactor. It is the inh-nad adduct that acts as a slow, tight-binding competitive inhibitor of inha
Ethambutol inhibits arabinosyl transferases which is involved in cell wall biosynthesis. By inhibiting this enzyme, the bacterial cell wall complex production is inhibited. This leads to an increase in cell wall permeability
ISONIAZID
Isoniazid is a prodrug and must be activated by bacterial catalase. Specficially, activation is associated with reduction of the mycobacterial ferric katg catalase-peroxidase by hydrazine and reaction with oxygen to form an oxyferrous enzyme complex. Once activated, isoniazid inhibits the synthesis of mycoloic acids, an essential component of the bacterial cell wall. At therapeutic levels isoniazid is bacteriocidal against actively growing intracellular and extracellular mycobacterium tuberculosis organisms. Specifically isoniazid inhibits inha, the enoyl reductase from mycobacterium tuberculosis, by forming a covalent adduct with the nad cofactor. It is the inh-nad adduct that acts as a slow, tight-binding competitive inhibitor of inha
Note
Mynah 250 "250mg, 100mg" Tablets manufactured by LEDERLE LAB (DIV.CYANAMIDE CO. GREAT BRITAIN). Its generic name is Ethambutol, Isoniazid. Mynah 250 is availble in United Arab Emirates.
Farmaco UAE drug index information on Mynah 250 Tablets is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.