Neodex Eye / Ear Drops (Solution)
Neomycin sulphate, Dexamethasone sodium phosphate
"5mg, 1mg/ml"
Amman Pharmaceutical Industries Co. Ltd.
| Pack size | 10ml Dropper Bottle |
|---|---|
| Dispensing mode | POM |
| Source | JORDAN |
| Agent | ARABIAN ETHICALS CO. |
| Retail Price | 8.00 AED |
Indications
Neodex Eye / Ear Drops (Solution) is used for:
NEOMYCIN
Topical uses include treatment for superficial eye infections caused by susceptible bacteria (used in combination with other antiinfectives), treatment of otitis externa caused by susceptible bacteria, treatment or prevention of bacterial infections in skin lesions, and use as a continuous short-term irrigant or rinse to prevent bacteriuria and gram negative rod bacteremia in abacteriuric patients with indwelling catheters. May be used orally to treat hepatic encephalopathy, as a perioperative prophylactic agent, and as an adjunct to fluid and electrolyte replacement in the treatment of diarrhea caused to enteropathogenic e. Coli (epec)
DEXAMETHASONE
injection: for the treatment of endocrine disorders, rheumatic d=disorders, collagen diseases, dermatologic diseases, allergic statesc, ophthalmic diseases, gastrointestinal diseases, respiratory diseases, hematologic disorders, neoplastic diseases, edematous states, cerebral edema.
ophthalmic ointment and solution: for the treatment of steroid responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe.
ophthalmic solution only: for the treatment of steroid responsive inflammatory conditions of the external auditory meatus
topic cream: for relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses
oral aerosol: for the treatment of bronchial asthma and related corticosteroid responsive bronchospastic states intractable to adequate trial of conventional therapy
intranasal aerosol: for the treatment of allergic ot inflammatory nasal conditions, and nasal polyps
Topical uses include treatment for superficial eye infections caused by susceptible bacteria (used in combination with other antiinfectives), treatment of otitis externa caused by susceptible bacteria, treatment or prevention of bacterial infections in skin lesions, and use as a continuous short-term irrigant or rinse to prevent bacteriuria and gram negative rod bacteremia in abacteriuric patients with indwelling catheters. May be used orally to treat hepatic encephalopathy, as a perioperative prophylactic agent, and as an adjunct to fluid and electrolyte replacement in the treatment of diarrhea caused to enteropathogenic e. Coli (epec)
DEXAMETHASONE
injection: for the treatment of endocrine disorders, rheumatic d=disorders, collagen diseases, dermatologic diseases, allergic statesc, ophthalmic diseases, gastrointestinal diseases, respiratory diseases, hematologic disorders, neoplastic diseases, edematous states, cerebral edema.
ophthalmic ointment and solution: for the treatment of steroid responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe.
ophthalmic solution only: for the treatment of steroid responsive inflammatory conditions of the external auditory meatus
topic cream: for relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses
oral aerosol: for the treatment of bronchial asthma and related corticosteroid responsive bronchospastic states intractable to adequate trial of conventional therapy
intranasal aerosol: for the treatment of allergic ot inflammatory nasal conditions, and nasal polyps
Adult Dose
Child Dose
Renal Dose
Administration
Contra Indications
Precautions
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Neomycin sulphate, Dexamethasone sodium phosphate :
Mechanism of Action
NEOMYCIN
Aminoglycosides like neomycin "irreversibly" bind to specific 30s-subunit proteins and 16s rrna. Specifically neomycin binds to four nucleotides of 16s rrna and a single amino acid of protein s12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16s rrna of 30s subunit. This region interacts with the wobble base in the anticodon of trna. This leads to interference with the initiation complex, misreading of mrna so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes
DEXAMETHASONE
Dexamethasone is a glucocorticoid agonist. Unbound dexamethasone crosses cell membranes and binds with high affinity to specific cytoplasmic glucocorticoid receptors. This complex binds to dna elements (glucocorticoid response elements) which results in a modification of transcription and, hence, protein synthesis in order to achieve inhibition of leukocyte infiltration at the site of inflammation, interference in the function of mediators of inflammatory response, suppression of humoral immune responses, and reduction in edema or scar tissue. The antiinflammatory actions of dexamethasone are thought to involve phospholipase a2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes
Aminoglycosides like neomycin "irreversibly" bind to specific 30s-subunit proteins and 16s rrna. Specifically neomycin binds to four nucleotides of 16s rrna and a single amino acid of protein s12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16s rrna of 30s subunit. This region interacts with the wobble base in the anticodon of trna. This leads to interference with the initiation complex, misreading of mrna so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes
DEXAMETHASONE
Dexamethasone is a glucocorticoid agonist. Unbound dexamethasone crosses cell membranes and binds with high affinity to specific cytoplasmic glucocorticoid receptors. This complex binds to dna elements (glucocorticoid response elements) which results in a modification of transcription and, hence, protein synthesis in order to achieve inhibition of leukocyte infiltration at the site of inflammation, interference in the function of mediators of inflammatory response, suppression of humoral immune responses, and reduction in edema or scar tissue. The antiinflammatory actions of dexamethasone are thought to involve phospholipase a2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes
Note
Neodex "5mg, 1mg/ml" Eye / Ear Drops (Solution) manufactured by Amman Pharmaceutical Industries Co. Ltd.. Its generic name is Neomycin sulphate, Dexamethasone sodium phosphate. Neodex is availble in United Arab Emirates.
Farmaco UAE drug index information on Neodex Eye / Ear Drops (Solution) is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.