Neosporin Eye Drops
Gramicidin, Neomycin sulphate, Polymyxin B sulphate
"25iu, 2.5mg, 5000iu/ml"
The Wellcome Foundation Limited
| Pack size | 5ml |
|---|---|
| Dispensing mode | POM |
| Source | UK |
| Agent | AL BAKER TRADING EST. |
| Retail Price | 15.50 AED |
Indications
Neosporin Eye Drops is used for:
GRAMICIDIN D
For treatment of skin lesions, surface wounds and eye infections
NEOMYCIN
Topical uses include treatment for superficial eye infections caused by susceptible bacteria (used in combination with other antiinfectives), treatment of otitis externa caused by susceptible bacteria, treatment or prevention of bacterial infections in skin lesions, and use as a continuous short-term irrigant or rinse to prevent bacteriuria and gram negative rod bacteremia in abacteriuric patients with indwelling catheters. May be used orally to treat hepatic encephalopathy, as a perioperative prophylactic agent, and as an adjunct to fluid and electrolyte replacement in the treatment of diarrhea caused to enteropathogenic e. Coli (epec)
POLYMYXIN B SULFATE
For treatment of infections of the urinary tract, meninges, and blood stream, caused by susceptible strains of pseudomonas aeruginosa
For treatment of skin lesions, surface wounds and eye infections
NEOMYCIN
Topical uses include treatment for superficial eye infections caused by susceptible bacteria (used in combination with other antiinfectives), treatment of otitis externa caused by susceptible bacteria, treatment or prevention of bacterial infections in skin lesions, and use as a continuous short-term irrigant or rinse to prevent bacteriuria and gram negative rod bacteremia in abacteriuric patients with indwelling catheters. May be used orally to treat hepatic encephalopathy, as a perioperative prophylactic agent, and as an adjunct to fluid and electrolyte replacement in the treatment of diarrhea caused to enteropathogenic e. Coli (epec)
POLYMYXIN B SULFATE
For treatment of infections of the urinary tract, meninges, and blood stream, caused by susceptible strains of pseudomonas aeruginosa
Adult Dose
Child Dose
Renal Dose
Administration
Contra Indications
Precautions
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Gramicidin, Neomycin sulphate, Polymyxin B sulphate :
Mechanism of Action
GRAMICIDIN D
Gramicidin d binds to and inserts itself into bacterial membranes (with a strong preference to gram-positive cell membranes). This results in membrane disruption and permeabilization (it acts as a channel). This leads to (i) loss of intracellular solutes (e. G. , k+ and amino acids); (ii) dissipation of the transmembrane potential; (iii) inhibition of respiration; (iv) a reduction in atp pools; and (v) inhibition of dna, rna, and protein synthesis, which leads to cell death
NEOMYCIN
Aminoglycosides like neomycin "irreversibly" bind to specific 30s-subunit proteins and 16s rrna. Specifically neomycin binds to four nucleotides of 16s rrna and a single amino acid of protein s12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16s rrna of 30s subunit. This region interacts with the wobble base in the anticodon of trna. This leads to interference with the initiation complex, misreading of mrna so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes
POLYMYXIN B SULFATE
Polymyxin b sulfate has a bactericidal action against almost all gram-negative bacilli except the proteus group. Polymyxin b sulfate interacts with the lipopolysaccharide of the cytoplasmic outer membrane of gram-negative bacteria, altering membrane permeability and causing cell death. It does not need to enter the cell
Gramicidin d binds to and inserts itself into bacterial membranes (with a strong preference to gram-positive cell membranes). This results in membrane disruption and permeabilization (it acts as a channel). This leads to (i) loss of intracellular solutes (e. G. , k+ and amino acids); (ii) dissipation of the transmembrane potential; (iii) inhibition of respiration; (iv) a reduction in atp pools; and (v) inhibition of dna, rna, and protein synthesis, which leads to cell death
NEOMYCIN
Aminoglycosides like neomycin "irreversibly" bind to specific 30s-subunit proteins and 16s rrna. Specifically neomycin binds to four nucleotides of 16s rrna and a single amino acid of protein s12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16s rrna of 30s subunit. This region interacts with the wobble base in the anticodon of trna. This leads to interference with the initiation complex, misreading of mrna so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes
POLYMYXIN B SULFATE
Polymyxin b sulfate has a bactericidal action against almost all gram-negative bacilli except the proteus group. Polymyxin b sulfate interacts with the lipopolysaccharide of the cytoplasmic outer membrane of gram-negative bacteria, altering membrane permeability and causing cell death. It does not need to enter the cell
Note
Neosporin "25iu, 2.5mg, 5000iu/ml" Eye Drops manufactured by The Wellcome Foundation Limited. Its generic name is Gramicidin, Neomycin sulphate, Polymyxin B sulphate. Neosporin is availble in United Arab Emirates.
Farmaco UAE drug index information on Neosporin Eye Drops is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.