Noradran Syrup
Diprophylline, Ephedrine HCl, Guaiphenesin, Diphenhydramine HCl
"50mg, 7.5mg, 25mg, 5mg/5ml"
WALLACE (NORMA CHEMICALS)
| Pack size | 75ml Bottle |
|---|---|
| Dispensing mode | POM |
| Source | UK |
| Agent | ARABIAN ETHICALS CO. |
| Retail Price | 5.50 AED |
Indications
Noradran Syrup is used for:
DYPHYLLINE
For relief of acute bronchial asthma and for reversible bronchospasm associated with chronic bronchitis and emphysema
EPHEDRINE
Ephedrine commonly used as a stimulant, appetite suppressant, concentration aid, decongestant, and to treat hypotension associated with anaesthesia
GUAIFENESIN
Used to assist the expectoration of phlegm from the airways in acute respiratory tract infections
DIPHENHYDRAMINE
For the treatment of symptoms associated with vertigo/meniere's disease, nausea and vomiting, motion sickness and insect bite
For relief of acute bronchial asthma and for reversible bronchospasm associated with chronic bronchitis and emphysema
EPHEDRINE
Ephedrine commonly used as a stimulant, appetite suppressant, concentration aid, decongestant, and to treat hypotension associated with anaesthesia
GUAIFENESIN
Used to assist the expectoration of phlegm from the airways in acute respiratory tract infections
DIPHENHYDRAMINE
For the treatment of symptoms associated with vertigo/meniere's disease, nausea and vomiting, motion sickness and insect bite
Adult Dose
Child Dose
Renal Dose
Administration
Contra Indications
Precautions
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Diprophylline, Ephedrine HCl, Guaiphenesin, Diphenhydramine HCl :
Mechanism of Action
DYPHYLLINE
The bronchodilatory action of dyphylline, as with other xanthines, is thought to be mediated through competitive inhibition of phosphodiesterase with a resulting increase in cyclic amp producing relaxation of bronchial smooth muscle as well as antagonism of adenosine receptors
EPHEDRINE
Ephedrine is a sympathomimetic amine - that is, its principal mechanism of action relies on its direct and indirect actions on the adrenergic receptor system, which is part of the sympathetic nervous system. Ephedrine increases post-synaptic noradrenergic receptor activity by (weakly) directly activating post-synaptic a-receptors and >-receptors, but the bulk of its effect comes from the pre-synaptic neuron being unable to distinguish between real adrenaline or noradrenaline from ephedrine. The ephedrine, mixed with noradrenaline, is transported through the noradrenaline reuptake complex and packaged (along with real noradrenaline) into vesicles that reside at the terminal button of a nerve cell. Ephedrine's action as an agonist at most major noradrenaline receptors and its ability to increase the release of both dopamine and to a lesser extent, serotonin by the same mechanism is presumed to have a major role in its mechanism of action
GUAIFENESIN
Guaifenesin may act as an irritant to gastric vagal receptors, and recruit efferent parasympathetic reflexes that cause glandular exocytosis of a less viscous mucus mixture. Cough may be provoked. This combination may flush tenacious, congealed mucopurulent material from obstructed small airways and lead to a temporary improvement in dyspnea or the work of breathing
DIPHENHYDRAMINE
Diphenhydramine competes with free histamine for binding at ha-receptor sites. This antagonizes the effects of histamine on ha-receptors, leading to a reduction of the negative symptoms brought on by histamine ha-receptor binding
The bronchodilatory action of dyphylline, as with other xanthines, is thought to be mediated through competitive inhibition of phosphodiesterase with a resulting increase in cyclic amp producing relaxation of bronchial smooth muscle as well as antagonism of adenosine receptors
EPHEDRINE
Ephedrine is a sympathomimetic amine - that is, its principal mechanism of action relies on its direct and indirect actions on the adrenergic receptor system, which is part of the sympathetic nervous system. Ephedrine increases post-synaptic noradrenergic receptor activity by (weakly) directly activating post-synaptic a-receptors and >-receptors, but the bulk of its effect comes from the pre-synaptic neuron being unable to distinguish between real adrenaline or noradrenaline from ephedrine. The ephedrine, mixed with noradrenaline, is transported through the noradrenaline reuptake complex and packaged (along with real noradrenaline) into vesicles that reside at the terminal button of a nerve cell. Ephedrine's action as an agonist at most major noradrenaline receptors and its ability to increase the release of both dopamine and to a lesser extent, serotonin by the same mechanism is presumed to have a major role in its mechanism of action
GUAIFENESIN
Guaifenesin may act as an irritant to gastric vagal receptors, and recruit efferent parasympathetic reflexes that cause glandular exocytosis of a less viscous mucus mixture. Cough may be provoked. This combination may flush tenacious, congealed mucopurulent material from obstructed small airways and lead to a temporary improvement in dyspnea or the work of breathing
DIPHENHYDRAMINE
Diphenhydramine competes with free histamine for binding at ha-receptor sites. This antagonizes the effects of histamine on ha-receptors, leading to a reduction of the negative symptoms brought on by histamine ha-receptor binding
Note
Noradran "50mg, 7.5mg, 25mg, 5mg/5ml" Syrup manufactured by WALLACE (NORMA CHEMICALS). Its generic name is Diprophylline, Ephedrine HCl, Guaiphenesin, Diphenhydramine HCl. Noradran is availble in United Arab Emirates.
Farmaco UAE drug index information on Noradran Syrup is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.