Novatretin Capsules (Hard Gelatin)
Acitretin
10mg
DOUGLAS MANUFACTURING LTD.
| Pack size | 30's (10's Blister x 3) |
|---|---|
| Dispensing mode | POM |
| Source | NEW ZEALAND |
| Agent | PHARMALINK |
| Retail Price | 88.50 AED |
Available as:
Indications
Novatretin Capsules (Hard Gelatin) is used for:
Lichen planus, Psoriasis, Congenital icthyosis, Darier's disease
Adult Dose
Oral
Darier's disease
Adult: Initially, 10 mg daily for 2-4 wk. Max: 50 mg/day.
Congenital icthyosis
Adult: Initially, 25-30 mg daily for 2-4 wk before dose adjustments are done. Usual range: 25-50 mg daily for further 6-8 wk. Max: 75 mg daily for short periods.
Severe psoriasis
Adult: Initially, 25-30 mg daily for 2-4 wk before dose adjustments are done. Usual range: 25-50 mg daily for further 6-8 wk. Max: 75 mg daily for short periods.
Severe lichen planus
Adult: Initially, 25-30 mg daily for 2-4 wk before dose adjustments are done. Usual range: 25-50 mg daily for further 6-8 wk. Max: 75 mg daily for short periods.
Child Dose
Renal Dose
Administration
Should be taken with food. Take w/ main meals or w/ a glass of milk.
Contra Indications
Pregnancy (before the start, during and at least 2-3 yr after cessation of therapy), lactation. Hepatic and renal impairment. Hyperlipidaemia.
Precautions
Female patients to avoid alcohol during and 2 mth after treatment. Avoid blood donation during therapy or at least 1-3 yr after stopping therapy. Children. Radiographic treatment for prolonged therapy. Therapy should not last >6 mth. Monitor plasma lipid and glucose levels (especially diabetics) regularly. Monitor LFTs.
Lactation: enters breast milk/not recommended.
Pregnancy-Lactation
Pregnancy Category: X
Major human fetal abnormalities have been reported including meningomyelocele, meningoencephalocele, multiple synostoses, facial dysmorphia, syndactyly, absence of terminal phalanges, malformations of bones (hip, ankle, forearm, skull, cerebral vertebrae), low-set ears, high palate, decreased cranial volume, and cardiovascular malformations
Lactation: enters breast milk/not recommended
Interactions
Concomitant use with keratolytics or high dose vitamin A. Reduces anticoagulant effect of coumarins e.g. warfarin. Concomitant use of microdised progestin oral contraceptives. Concomitant use of methotrexate can potentiate hepatotoxicty. Concomitant use with tetracycline.
Adverse Effects
Side effects of Acitretin :
Cheilitis (>75%), Alopecia (50-75%), Hypertriglyceridemia (50-75%), Skin peeling (50-75%), Dry skin (25-50%), Dysglycemia (25-50%), Increased LFT (25-50%), Nail disorder (25-50%), Pruritus (25-50%), Rhinitis (25-50%), Arthralgia (10-25%), Changes in phosphorus, potassium, sodium, & magnesium levels (10-25%), Dry mouth (10-25%), Epistaxis (10-25%), Erythematous rash (10-25%), Hepatotoxicity (10-25%), Hyperesthesia (10-25%), Paresthesia (10-25%), Paronychia (10-25%), Rigors (10-25%), Skin atrophy (10-25%), Spinal hyperostosis (10-25%), Sticky skin (10-25%), Xerophthalmia (10-25%)
1-10%
Edema, Flushing, Depression, Fatigue, Headache, Insomnia, Somnolence, Abdominal pain, Anorexia, Diarrhea, Gingivitis, Increased appetite, Nausea, Stomatitis, Vomiting, Hot flashes, Vision changes, Corneal epithelial abnormality, Sinusitis
Potentially Fatal: Phototoxicity, jaundice, hepatitis and hepatotoxity.
Mechanism of Action
Acitretin is an active metabolite of etretinate but its mechanism of action is unknown.
Note
Novatretin 10mg Capsules (Hard Gelatin) manufactured by DOUGLAS MANUFACTURING LTD.. Its generic name is Acitretin. Novatretin is availble in United Arab Emirates.
Farmaco UAE drug index information on Novatretin Capsules (Hard Gelatin) is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.