NOVOMIX 70 Penfill Injection
Insulin - Aspart biphasic (human recombinant) (70% aspart, 30% aspart protamin)
100 IU/ml
Novo Nordisk A/S
| Pack size | 3ml Cartridge x 5 |
|---|---|
| Dispensing mode | POM |
| Source | DENMARK |
| Agent | CITY MEDICAL STORE |
| Retail Price | 186.50 AED |
Available as:
Indications
NOVOMIX 70 Penfill Injection is used for:
For the treatment of Type 1 or 2 diabetes mellitus. Should normally be used in conjunction with an intermediate or long-acting insulin.
Adult Dose
Child Dose
Renal Dose
Administration
Contra Indications
Precautions
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Insulin - Aspart biphasic (human recombinant) (70% aspart, 30% aspart protamin) :
Mechanism of Action
Insulin aspart binds to the insulin receptor (IR), a heterotetrameric protein consisting of two extracellular alpha units and two transmembrane beta units. The binding of insulin to the alpha subunit of IR stimulates the tyrosine kinase activity intrinsic to the beta subunit of the receptor. The bound receptor autophosphorylates and phosphorylates numerous intracellular substrates such as insulin receptor substrates (IRS) proteins, Cbl, APS, Shc and Gab 1. Activation of these proteins leads to the activation of downstream signaling molecules including PI3 kinase and Akt. Akt regulates the activity of glucose transporter 4 (GLUT4) and protein kinase C (PKC), both of which play critical roles in metabolism and catabolism. In humans, insulin is stored in the form of hexamers; however, only insulin monomers are able to interact with IR. Substitution of the proline residue at B28 with aspartic acid reduces the tendency to form hexamers and results in a faster rate of absorption and onset of action and shorter duration of action.
Note
NOVOMIX 70 Penfill 100 IU/ml Injection manufactured by Novo Nordisk A/S. Its generic name is Insulin - Aspart biphasic (human recombinant) (70% aspart, 30% aspart protamin). NOVOMIX 70 Penfill is availble in United Arab Emirates.
Farmaco UAE drug index information on NOVOMIX 70 Penfill Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.