Odrik Capsules (Hard Gelatin)

Trandolapril
0.5mg
ABBOTT GmbH & CO. KG
Pack size 28's (14's Blister x 2)
Dispensing mode POM
Source GERMANY
AgentGULF DRUG EST.
Retail Price 22.50 AED

Indications

Odrik Capsules (Hard Gelatin) is used for: Hypertension

Adult Dose

Hypertension In patients not taking a diuretic Initial dose 1 mg PO qDay in nonblack patients 2 mg PO qDay in black patients Maintenance dose 2-4 mg PO qDay; may divide q12hr if BP response diminishes Congestive Heart Failure or Left Ventricular Dysfunction Post-MI Initial: 1 mg PO qDay Maintenance: 4 mg PO qDay

Child Dose

Renal Dose

Dosage Modifications Renal impairment (CrCl <30 mL/min): 0.5 mg PO qDay Hepatic impairment (cirrhosis): 0.5 mg PO qDay

Administration

Contra Indications

Hypersensitivity History of hereditary or angioedema associated with previous ACE inhibitor treatment Coadministration of neprilysin inhibitors (eg, sacubitril) with ACE inhibitors may increase angioedema risk; do not administer ACE inhibitors within 36 hr of switching to or from sacubitril/valsartan Bilateral renal artery stenosis Do not coadminister with aliskiren in patients with diabetes mellitus or with renal impairment (ie, GFR <60 mL/min/1.73 m²)

Precautions

Less effective in Blacks Excessive hypotension if concomitant diuretics, hypovolemia, hyponatremia Renal impairment may occur Coadministration with mTOR inhibitors (eg, temsirolimus, sirolimus, everolimus) may increased risk for angioedema Neutropenia/agranulocytosis reported Cough may occur within the first few months Cholestatic jaundice may occur Risk of hyperkalemia, especially in renal impairment, diabetes melliuts, or coadministration with potassium-elevating drugs ACE inhibition also causes increased bradykinin levels which putatively mediates angioedema; higher incidence of angioedema in black than nonblack patients Dual blockade of the renin angiotensin system with ARBs, ACE inhibitors, or aliskiren associated with increased risk for hypotension, hyperkalemia, and renal function changes (including acute renal failure) compared to monotherapy Intestinal angioedema reported in patients treated with ACE inhibitors; it should be included in differential diagnosis of patients, taking ACE inhibitors and presenting with abdominal pain

Pregnancy-Lactation

Pregnancy Category: C (1st trimester); D (2nd/3rd trimesters) Lactation: possibly excreted in breast milk; nursing not recommended

Interactions

Adverse Effects

Side effects of Trandolapril : >10% Cough (1.9-35%) Elevated Uric Acid (15%) Hypotension (1-11%) 1-10% Syncope (5.9%) Hyperkalemia (5.3%) Hypocalcemia (4.7%) Stroke (3.8%) Bradycardia (1-5%) Dizziness (1.3-2.3%) Frequency Not Defined Angioedema ARF if renal artery stenosis

Mechanism of Action

Angiotensin converting enzyme (ACE) inhibitors dilate arteries and veins by competively inhibiting the conversion of angiotensin I to angiotensin II (a potent endogenous vasoconstrictor) and by inhibiting bradykinin metabolism; these actions result in preload and afterload reductions on the heart ACE inhibitors also promote sodium and water excretion by inhibiting angiotensin-II induced aldosterone secretion; elevation in potassium may also be observed ACE inhibitors also elicit renoprotective effects through vasodilation of renal arterioles ACE inhibitors reduce cardiac and vascular remodeling associated with chronic hypertension, heart failure, and myocardial infarction

Note

Odrik 0.5mg Capsules (Hard Gelatin) manufactured by ABBOTT GmbH & CO. KG. Its generic name is Trandolapril. Odrik is availble in United Arab Emirates. Farmaco UAE drug index information on Odrik Capsules (Hard Gelatin) is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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