Odrik Capsules (Hard Gelatin)
Trandolapril
0.5mg
ABBOTT GmbH & CO. KG
| Pack size | 28's (14's Blister x 2) |
|---|---|
| Dispensing mode | POM |
| Source | GERMANY |
| Agent | GULF DRUG EST. |
| Retail Price | 22.50 AED |
Available as:
Indications
Odrik Capsules (Hard Gelatin) is used for:
Hypertension
Adult Dose
Hypertension
In patients not taking a diuretic
Initial dose
1 mg PO qDay in nonblack patients
2 mg PO qDay in black patients
Maintenance dose
2-4 mg PO qDay; may divide q12hr if BP response diminishes
Congestive Heart Failure or Left Ventricular Dysfunction Post-MI
Initial: 1 mg PO qDay
Maintenance: 4 mg PO qDay
Child Dose
Renal Dose
Dosage Modifications
Renal impairment (CrCl <30 mL/min): 0.5 mg PO qDay
Hepatic impairment (cirrhosis): 0.5 mg PO qDay
Administration
Contra Indications
Hypersensitivity
History of hereditary or angioedema associated with previous ACE inhibitor treatment
Coadministration of neprilysin inhibitors (eg, sacubitril) with ACE inhibitors may increase angioedema risk; do not administer ACE inhibitors within 36 hr of switching to or from sacubitril/valsartan
Bilateral renal artery stenosis
Do not coadminister with aliskiren in patients with diabetes mellitus or with renal impairment (ie, GFR <60 mL/min/1.73 m²)
Precautions
Less effective in Blacks
Excessive hypotension if concomitant diuretics, hypovolemia, hyponatremia
Renal impairment may occur
Coadministration with mTOR inhibitors (eg, temsirolimus, sirolimus, everolimus) may increased risk for angioedema
Neutropenia/agranulocytosis reported
Cough may occur within the first few months
Cholestatic jaundice may occur
Risk of hyperkalemia, especially in renal impairment, diabetes melliuts, or coadministration with potassium-elevating drugs
ACE inhibition also causes increased bradykinin levels which putatively mediates angioedema; higher incidence of angioedema in black than nonblack patients
Dual blockade of the renin angiotensin system with ARBs, ACE inhibitors, or aliskiren associated with increased risk for hypotension, hyperkalemia, and renal function changes (including acute renal failure) compared to monotherapy
Intestinal angioedema reported in patients treated with ACE inhibitors; it should be included in differential diagnosis of patients, taking ACE inhibitors and presenting with abdominal pain
Pregnancy-Lactation
Pregnancy Category: C (1st trimester); D (2nd/3rd trimesters)
Lactation: possibly excreted in breast milk; nursing not recommended
Interactions
Adverse Effects
Side effects of Trandolapril :
>10%
Cough (1.9-35%)
Elevated Uric Acid (15%)
Hypotension (1-11%)
1-10%
Syncope (5.9%)
Hyperkalemia (5.3%)
Hypocalcemia (4.7%)
Stroke (3.8%)
Bradycardia (1-5%)
Dizziness (1.3-2.3%)
Frequency Not Defined
Angioedema
ARF if renal artery stenosis
Mechanism of Action
Angiotensin converting enzyme (ACE) inhibitors dilate arteries and veins by competively inhibiting the conversion of angiotensin I to angiotensin II (a potent endogenous vasoconstrictor) and by inhibiting bradykinin metabolism; these actions result in preload and afterload reductions on the heart
ACE inhibitors also promote sodium and water excretion by inhibiting angiotensin-II induced aldosterone secretion; elevation in potassium may also be observed
ACE inhibitors also elicit renoprotective effects through vasodilation of renal arterioles
ACE inhibitors reduce cardiac and vascular remodeling associated with chronic hypertension, heart failure, and myocardial infarction
Note
Odrik 0.5mg Capsules (Hard Gelatin) manufactured by ABBOTT GmbH & CO. KG. Its generic name is Trandolapril. Odrik is availble in United Arab Emirates.
Farmaco UAE drug index information on Odrik Capsules (Hard Gelatin) is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.