Oflacin Tablets
Ofloxacin
200mg
RAM PHARMACEUTICAL INDUSTRIES CO. LTD.
| Pack size | 10's Blister |
|---|---|
| Dispensing mode | POM |
| Source | JORDAN |
| Agent | AL MAZROUI MEDICAL & CHEMICAL SUPPLIES |
| Retail Price | 31.00 AED |
Indications
Oflacin Tablets is used for:
Leprosy, chronic bronchitis, Community-acquired pneumonia, Uncomplicated skin infections, anthrax, Legionnaire's disease, Nongonococcal cervicitis, Urethritis, Uncomplicated cystitis, Complicated UTI, Traveller's diarrhea, bacterial prostatis, Typhoid fever, Skin and soft tissue infections, Uncomplicated gonorrhea, Pelvic inflammatory disease, Lower respiratory tract infections, Septicaemia
Adult Dose
Oral
Bronchitis Exacerbation, Community Acquired Pneumonia, Skin & Skin Structure Infections
Adult: 400 mg bid for 10 days.
Uncomplicated gonorrhoea
Adult: 400 mg as a single dose.
Nongonococcal Cervicitis/Urethritis
Adult: 400 mg daily in single or divided doses for 7 days.
Uncomplicated Cystitis
Adult: 200 mg bid for 3-7 days.
Complicated UTIs
Adult: 200 mg bid for 10 days.
Pelvic inflammatory disease
Adult: 400 mg bid for 10-14 days.
Prostatitis
Adult: Acute or chronic: 200 mg bid for 28 days.
Intravenous
Complicated urinary tract infections
Adult: 200 mg daily by infusion over at least 30 min. Max: 400 mg bid infused over at least 1 hr.
Lower respiratory tract infections; Septicaemia
Adult: 200 mg bid by infusion over at least 30 min. Max: 400 mg bid infused over at least 1 hr.
Skin and soft tissue infections
Adult: 400 mg bid infused over at least 1 hr.
Hepatic impairment: Severe: Reduce dose. Max: 400 mg daily.
Child Dose
Not indicated
Renal Dose
Renal impairment:
CrCl (ml/min) Dosage Recommendation
20-50 Reduce dose by half 24 hrly following usual initial dose.
<20 and patients on haemodialysis or peritoneal dialysis 100 mg 24 hrly following usual initial dose..
Administration
May be taken with or without food. Avoid antacids or supplements containing Fe or Znor or dairy products w/in 2 hr before or after ofloxacin.
Ensure adequate hydration.
Contra Indications
Hypersensitivity to quinolones; pregnancy and lactation; prolongation of the QT interval; uncorrected hypokalaemia.
Precautions
Epilepsy or other predisposition to seizures; known or suspected CNS disorders; renal, hepatic impairment; myasthaenia gravis; superinfection; children <18 yr; exposure to strong sunlight and UV light; ensure adequate hydration; elderly.
Lactation: excreted in breast milk, discontinue drug or do not nurse
Pregnancy-Lactation
Interactions
Concomitant use of class IA (e.g. quinidine, procainamide) or class III (e.g. amiodarone, sotalol) antiarrhythmic agents may increase risk of QT interval prolongation. Decreased serum and urine concentrations w/ antacids containing Mg, Al or Ca. Additive antibacterial activity w/ aminoglycosides (e.g. amikacin, tobramycin). Corticosteroids may increase risk of severe tendon disorders. Increased risk of CNS stimulation (e.g. seizures) w/ NSAIDs. Higher and prolonged serum theophylline concentrations and increased risk of theophylline-related adverse effects.
Adverse Effects
Side effects of Ofloxacin :
1-10%
Nausea (3-10%), Headache (1-9%), Insomnia (3-7%), Dizziness (1-5%), Vaginitis (1-5%), Diarrhea (1-4%), Vomiting (1-4%), Appetite decreased (1-3%), Abdominal cramps (1-3%), Abnormal taste (1-3%), Chest pain (1-3%), External genital pruritis in women (1-3%), Fatigue (1-3%), Flatulence (1-3%), GI distress (1-3%), Nervousness (1-3%), Pharyngitis (1-3%), Pyrexia (1-3%), Rash/pruritis (1-3%), Sleep disorders (1-3%), Visual disturbances (1-3%), Xerostomia (1-3%)
<1%
Prolonged QT interval, Torsades de pointes, Syncope, Vasculitis, Edema, HTN, Palpitations, Vasodilation, Stevens-Johnson syndrome, Toxic epidermal necrolysis, Agranulocytosis, Aplastic anemia, Pancytopenia, Thrombocytopenia, Thrombocytopenic purpura, Acute hepatitis, Hepatic failure, Hepatic necrosiImmune hypersensitivity reaction, Rupture of tendon, Tendinitis, Peripheral neuropathy, Seizure, Acute renal failure, Interstitial nephritis, Renal impairment, Tourette's syndrome, Decrease hearing acuity, Tinnitus
Potentially Fatal: Anaphylaxis; rarely seizures.
Mechanism of Action
Ofloxacin is a fluoroquinolone which inhibits bacterial topoisomerase IV and DNA gyrase enzymes required for DNA replication, transcription, repair and recombination. It has activity against a wide range of gram-negative and gram-positive microorganisms.
Note
Oflacin 200mg Tablets manufactured by RAM PHARMACEUTICAL INDUSTRIES CO. LTD.. Its generic name is Ofloxacin. Oflacin is availble in United Arab Emirates.
Farmaco UAE drug index information on Oflacin Tablets is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.