One-Alpha Drops (Oral)

Alfacalcidol
2mcg/ml
LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LEO PHARMA A/S)
Pack size 20ml
Dispensing mode POM
Source DENMARK
AgentPHARMATRADE
Retail Price 103.50 AED

Indications

One-Alpha Drops (Oral) is used for: Hypoparathyroidism, Hypocalcaemia, Renal osteodystrophy, Hypophosphataemia, Rickets or osteomalacia

Adult Dose

Adult: PO Hypocalcaemia; Hypoparathyroidism; Hypophosphataemia; Renal osteodystrophy; Rickets or osteomalacia Initial: 1 mcg/day. Maintenance: 0.25-1 mcg/day. Elderly: 0.5 mcg daily.

Child Dose

Child: PO: Premature infants and neonates: 0.05-0.1 mcg/kg daily; <20 kg: 0.05 mcg/kg daily.

Renal Dose

Administration

Administration Should be taken with food.

Contra Indications

Hypercalcaemia, metastatic calcification, hyperphosphataemia (except when occurring with hypoparathyroidism), hypermagnesaemia.

Precautions

Pregnancy, lactation, renal impairment, infants, elderly. Monitor serum levels of calcium in patients with renal failure. Caution in hypercalciuria esp in those with history of renal calculi. Avoid in patients with hypersensitivity to inj. containing propylene glycol.

Pregnancy-Lactation

Interactions

Thiazides may increase the risk of hypercalcaemia. Some antiepileptics e.g. carbamazepine, phenobarbital, phenytoin and primidone may increase vitamin D requirements. Rifampicin, isoniazid and corticosteroids may reduce the efficacy of vitamin D.

Adverse Effects

Side effects of Alfacalcidol : Anorexia, nausea, vomiting, diarrhoea, lassitude, polyuria, sweating, headache, thirst, vertigo, pruritus, rash, urticaria. Hypercalcaemia, hypercalciuria and ectopic calcification. In case of renal impairment, hyperphosphataemia. In hypercalcaemic dialysis patients, possibility of calcium influx from the dialysate should be considered.

Mechanism of Action

Alfacalcidol is a precursor of the active calcitriol. It does not require renal hydroxylation but requires 25-hydroxylation in the liver for conversion to calcitriol.

Note

One-Alpha 2mcg/ml Drops (Oral) manufactured by LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LEO PHARMA A/S). Its generic name is Alfacalcidol. One-Alpha is availble in United Arab Emirates. Farmaco UAE drug index information on One-Alpha Drops (Oral) is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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