Oxycontin Tablets / Controlled-release
Oxycodone HCl
40mg
PURDUE PHARMACEUTICALS LP
| Pack size | 20's (10's Blister x 2) |
|---|---|
| Dispensing mode | CD-Narcotic |
| Source | USA |
| Agent | CITY MEDICAL STORE |
| Retail Price | 358.50 AED |
Available as:
Indications
Oxycontin Tablets / Controlled-release is used for:
For the treatment of diarrhoea, pulmonary oedema and for the relief of moderate to moderately severe pain.
Adult Dose
Child Dose
Renal Dose
Administration
Contra Indications
Precautions
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Oxycodone HCl :
Mechanism of Action
Oxycodone acts as a weak agonist at mu, kappa, and delta opioid receptors within the central nervous system (CNS). Oxycodone primarily affects mu-type opioid receptors, which are coupled with G-protein receptors and function as modulators, both positive and negative, of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine, and noradrenaline is inhibited. Opioids such as oxycodone also inhibit the release of vasopressin, somatostatin, insulin, and glucagon. Opioids close N-type voltage-operated calcium channels (kappa-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (mu and delta receptor agonist). This results in hyperpolarization and reduced neuronal excitability.
Note
Oxycontin 40mg Tablets / Controlled-release manufactured by PURDUE PHARMACEUTICALS LP. Its generic name is Oxycodone HCl. Oxycontin is availble in United Arab Emirates.
Farmaco UAE drug index information on Oxycontin Tablets / Controlled-release is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.