PHYLLOCONTIN CONTINUS (Paediatric) Tablets / Prolonged Release
Aminophylline
100mg
BARD PHARMACEUTICALS LTD.
| Pack size | 56's Bottle |
|---|---|
| Dispensing mode | POM |
| Source | UK |
| Agent | CITY MEDICAL STORE |
| Retail Price | 17.00 AED |
Available as:
Indications
PHYLLOCONTIN CONTINUS (Paediatric) Tablets / Prolonged Release is used for:
Asthma, Acute bronchospasm, Chronic bronchitis, Emphysema, COPD
Adult Dose
Oral
Chronic bronchospasm
Adult: As hydrate: Initially, 225-450 mg bid, increased if necessary.
Intravenous
Acute severe bronchospasm
Adult: Loading dose: 5 mg/kg (ideal body weight) or 250-500 mg (25 mg/ml) by slow inj or infusion over 20-30 min. Maintenance infusion dose: 0.5 mg/kg/hr. Max rate: 25 mg/min.
Elderly: Dose reduction may be ncessary.
Hepatic impairment: Dose reduction may be ncessary.
Child Dose
Oral
Chronic bronchospasm
Child: >3 yr: As modified-release hydrate: 12 mg/kg daily increased to 24 mg/kg daily in 2 divided doses after 1 wk.
Intravenous
Acute severe bronchospasm
Child: Loading dose: same as adult dose. Maintenance dose: 6 mth-9 yr: 1 mg/kg/hr and 10-16 yr: 0.8 mg/kg/hr.
Renal Dose
Administration
Should be taken on an empty stomach. Take on an empty stomach at least 1 hr before or 2 hr after meals.
Contra Indications
Hypersensitivity.
Precautions
Neonates, elderly, lactation, pregnancy, cardiac/hepatic diseases, peptic ulceration, hyperthyroidism, hypertension, epilepsy, heart failure, chronic alcoholism, acute febrile illness.
Pregnancy-Lactation
Interactions
Other xanthines. Clearance reduced by allopurinol, some antiarrhythmics, cimetidine, disulfiram, fluvoxamine, interferon-alpha, macrolide antibiotics, quinolones, oral contraceptives, thiabendazole and viloxazine. Clearance increased by phenytoin, anticonvulsants, ritonavir, rifampicin, sulfinpyrazone, cigarette smoking. Corticosteroids, diuretics, beta2-agonists.
Potentially Fatal: Increased risk of cardiac arrhythmias with sympathomimetics and halothane. Tachycardia with pancuronium. beta-blockers inhibit metabolism. Increased risk of convulsion with quinolones, ketamine.
Adverse Effects
Side effects of Aminophylline :
Nausea, vomiting, abdominal pain, diarrhoea, headache, insomnia, dizziness, anxiety, restlessness; tremor, palpitations.
Potentially Fatal: Convulsions, cardiac arrhythmias, hypotension and sudden death after too rapid IV injection.
Mechanism of Action
Aminophylline is a combination of theophylline and ethylenediamine. Ethylenediamine is inactive; it increases the solubility of theophylline in water. Theophylline relaxes bronchial smooth muscle. Suggested mechanisms are an increase in intracellular cAMP through inhibition of phosphodiesterase; adenosine receptor antagonism, prostaglandin antagonism and effects on intracellular calcium.
Note
PHYLLOCONTIN CONTINUS (Paediatric) 100mg Tablets / Prolonged Release manufactured by BARD PHARMACEUTICALS LTD.. Its generic name is Aminophylline. PHYLLOCONTIN CONTINUS (Paediatric) is availble in United Arab Emirates.
Farmaco UAE drug index information on PHYLLOCONTIN CONTINUS (Paediatric) Tablets / Prolonged Release is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.
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