Plendil Tablets

Felodipine
5mg
ASTRAZENECA AB
Pack size 100's Bottle
Dispensing mode POM
Source SWEDEN
AgentModern Pharmaceutical Co.
Retail Price 143.50 AED

Indications

Plendil Tablets is used for: Hypertension, Angina pectoris, Heart Failure

Adult Dose

Oral Hypertension Adult: Initially, 5 mg once daily in the morning, adjust according to response. Maintenance: 2.5-10 mg/day. Max: 20 mg/day. Angina pectoris, Heart Failure Adult: Initially, 5 mg/day, increased to 10 mg/day if necessary. Elderly: Initially, 2.5 mg once daily. Hepatic impairment: Initially, 2.5 mg once daily.

Child Dose

Renal Dose

Administration

May be taken with or without food. Take w/o food or w/ a light meal. Avoid grapefruit juice.

Contra Indications

Unstable angina pectoris, cardiogenic shock, aortic stenosis. Use w/in 1 mth of MI.

Precautions

Patients w/ heart failure, hypertrophic cardiomyopathy w/ outflow tract obstruction. Hepatic impairment. Elderly. Pregnancy and lactation. Monitoring Parameters Monitor BP and heart rate. Lactation: excretion in milk unknown/not recommended

Pregnancy-Lactation

Pregnancy Category: C Lactation: excretion in milk unknown/not recommended

Interactions

Plasma levels increased by CYP3A4 inhibitors (e.g. cimetidine, azole antifungals, erythromycin, ritonavir) and reduced CYP3A4 by inducers (e.g. phenytoin, carbamazepine, barbiturates). May increase concentration of tacrolimus.

Adverse Effects

Side effects of Felodipine : >10% Headache (11-15%) 1-10% Peripheral edema (2-17%), Flushing (4-7%), Dizziness (1.1-3.4%), Tachycardia (0.4-2.5%) Frequency Not Defined Gingival hyperplasia, Rash, Upper respiratory infection

Mechanism of Action

Felodipine relaxes coronary vascular smooth muscles by inhibiting Ca ions from entering the slow channels or select voltage-sensitive areas of vascular smooth muscles and myocardium during depolarisation. It also increases myocardial oxygen delivery in patients w/ vasospastic angina.

Note

Plendil 5mg Tablets manufactured by ASTRAZENECA AB. Its generic name is Felodipine. Plendil is availble in United Arab Emirates. Farmaco UAE drug index information on Plendil Tablets is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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