POLARAMINE EXPECTORANT Syrup
Dexchlorpheniramine maleate, Guaifenesin, Pseudoephedrine sulphate
"0.4mg, 20mg, 4mg/ml"
Schering-Plough Labo N.V.
| Pack size | 120ml Bottle |
|---|---|
| Dispensing mode | POM |
| Source | BELGIUM |
| Agent | ALPHAMED SHARJAH EST. |
| Retail Price | 8.00 AED |
Indications
POLARAMINE EXPECTORANT Syrup is used for:
PHENIRAMINE
Pheniramine is an antihistamine used to treat allergic conditions such as hay fever or urticaria
GUAIFENESIN
Used to assist the expectoration of phlegm from the airways in acute respiratory tract infections
PSEUDOEPHEDRINE
For the treatment of nasal congestion, sinus congestion, eustachian tube congestion, and vasomotor rhinitis, and as an adjunct to other agents in the optimum treatment of allergic rhinitis, croup, sinusitis, otitis media, and tracheobronchitis. Also used as first-line therapy of priapism
Pheniramine is an antihistamine used to treat allergic conditions such as hay fever or urticaria
GUAIFENESIN
Used to assist the expectoration of phlegm from the airways in acute respiratory tract infections
PSEUDOEPHEDRINE
For the treatment of nasal congestion, sinus congestion, eustachian tube congestion, and vasomotor rhinitis, and as an adjunct to other agents in the optimum treatment of allergic rhinitis, croup, sinusitis, otitis media, and tracheobronchitis. Also used as first-line therapy of priapism
Adult Dose
Child Dose
Renal Dose
Administration
Contra Indications
Precautions
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Dexchlorpheniramine maleate, Guaifenesin, Pseudoephedrine sulphate :
Mechanism of Action
PHENIRAMINE
Antihistamines such as pheniramine appear to compete with histamine for histamine h1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of h1- receptor sites and thereby reduce the intensity of allergic reactions and tissue injury response involving histamine release. Antihistamines suppress the histamine-induced wheal (swelling) and flare (vasodilation) response by blocking the binding of histamine to its receptors on nerves, vascular smooth muscle, glandular cells, endothelium, and mast cells. They effectively exert competitive antagonism of histamine for h1-receptors
GUAIFENESIN
Guaifenesin may act as an irritant to gastric vagal receptors, and recruit efferent parasympathetic reflexes that cause glandular exocytosis of a less viscous mucus mixture. Cough may be provoked. This combination may flush tenacious, congealed mucopurulent material from obstructed small airways and lead to a temporary improvement in dyspnea or the work of breathing
PSEUDOEPHEDRINE
Pseudoephedrine acts directly on both alpha- and, to a lesser degree, beta-adrenergic receptors. Through direct action on alpha-adrenergic receptors in the mucosa of the respiratory tract, pseudoephedrine produces vasoconstriction. Pseudoephedrine relaxes bronchial smooth muscle by stimulating beta2-adrenergic receptors. Like ephedrine, pseudoephedrine releasing norepinephrine from its storage sites, an indirect effect. This is its main and direct mechanism of action. The displaced noradrenaline is released into the neuronal synapse where it is free to activate the postsynaptic adrenergic receptors
Antihistamines such as pheniramine appear to compete with histamine for histamine h1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of h1- receptor sites and thereby reduce the intensity of allergic reactions and tissue injury response involving histamine release. Antihistamines suppress the histamine-induced wheal (swelling) and flare (vasodilation) response by blocking the binding of histamine to its receptors on nerves, vascular smooth muscle, glandular cells, endothelium, and mast cells. They effectively exert competitive antagonism of histamine for h1-receptors
GUAIFENESIN
Guaifenesin may act as an irritant to gastric vagal receptors, and recruit efferent parasympathetic reflexes that cause glandular exocytosis of a less viscous mucus mixture. Cough may be provoked. This combination may flush tenacious, congealed mucopurulent material from obstructed small airways and lead to a temporary improvement in dyspnea or the work of breathing
PSEUDOEPHEDRINE
Pseudoephedrine acts directly on both alpha- and, to a lesser degree, beta-adrenergic receptors. Through direct action on alpha-adrenergic receptors in the mucosa of the respiratory tract, pseudoephedrine produces vasoconstriction. Pseudoephedrine relaxes bronchial smooth muscle by stimulating beta2-adrenergic receptors. Like ephedrine, pseudoephedrine releasing norepinephrine from its storage sites, an indirect effect. This is its main and direct mechanism of action. The displaced noradrenaline is released into the neuronal synapse where it is free to activate the postsynaptic adrenergic receptors
Note
POLARAMINE EXPECTORANT "0.4mg, 20mg, 4mg/ml" Syrup manufactured by Schering-Plough Labo N.V.. Its generic name is Dexchlorpheniramine maleate, Guaifenesin, Pseudoephedrine sulphate. POLARAMINE EXPECTORANT is availble in United Arab Emirates.
Farmaco UAE drug index information on POLARAMINE EXPECTORANT Syrup is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.