PROFASI Infusion
Chorionic Gonadotrophin
1000 IU
SERONO INDUSTRI
| Pack size | 3 Ampoules (Dry) + 3 Solvent Ampoules (1ml) |
|---|---|
| Dispensing mode | POM |
| Source | ITALY |
| Agent | ARABIAN ETHICALS CO. |
| Retail Price | 24.00 AED |
Available as:
Indications
PROFASI Infusion is used for:
Anovulatory infertility, Adjunct to IVF procedures and other assisted conception techniques
Adult Dose
Intramuscular
Prepubertal cryptorchidism in males
Adult: 500-4000 u injected 3 times wkly. Treatment should continue for 1-2 mth after testicular descent.
Male infertility due to hypogonadotrophic hypogonadism
Adult: 500-4000 u injected 2-3 times wkly.
Anovulatory infertility
Adult: Single dose of 5000-10,000 u. Up to 3 repeated injections of up to 5000 u each may be given within the following 9 days to prevent corpus luteum insufficiency.
Delayed puberty associated with hypogonadism in males
Adult: Male: Initially, 500-1500 u twice a wk titrated against plasma-testosterone concentration.
Child Dose
Renal Dose
Administration
Contra Indications
Hypersensitivity; precocious puberty, prostatic carcinoma or other androgenic dependent neoplasm. Pregnancy and lactation.
Precautions
Discontinue therapy if signs of precocious puberty are seen in patients treated for cryptorchidism. Patients with cardiac or renal disease, epilepsy, migraine or asthma.
Pregnancy-Lactation
Interactions
Interactions of Human chorionic gonadotrophin with other medicines have not been investigated; interactions with commonly used medicinal products cannot be excluded.
Following administration, Human chorionic gonadotrophin may interfere for up to 10 days with the immunological determination of serum/urinary human chorionic gonadotropin (hCG), leading to a false positive pregnancy test.
Incompatibilities: In the absence of compatibility studies, Pregnyl must not be mixed with other medicinal products.
Adverse Effects
Side effects of Chorionic Gonadotrophin :
Headache, irritability, restlessness, depression, fatigue, oedema; precocious puberty, gynaecomastia; pain at Inj site; enlargement of preexisting ovarian cysts and possible rupture; arterial thromboembolism; shock; abdominal pain.
Potentially Fatal: Ovarian hyperstimulation syndrome (OHSS).
Mechanism of Action
Chorionic Gonadotrophin is a polypeptide hormone produced by the human placenta. It stimulates the production of gonadal steroid hormones by inducing interstitial cells (Leydig cells) of the testis to produce androgens and the corpus luteum of the ovary to produce progesterone.
Note
PROFASI 1000 IU Infusion manufactured by SERONO INDUSTRI. Its generic name is Chorionic Gonadotrophin. PROFASI is availble in United Arab Emirates.
Farmaco UAE drug index information on PROFASI Infusion is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.