PROFINAL XP Tablets / Film-coated
Ibuprofen, Caffeine
"400mg, 65mg"
Julphar (Gulf Pharmaceutical Industries)
| Pack size | 20's (10's Blister x 2) |
|---|---|
| Dispensing mode | POM |
| Source | UAE |
| Agent | JULPHAR |
| Retail Price | 17.00 AED |
Indications
PROFINAL XP Tablets / Film-coated is used for:
For symptomatic treatment of rheumatoid arthritis, juvenile rheumatoid arthritis and osteoarthritis. May be used to treat mild to moderate pain and for the management of dysmenorrhea. May be used to reduce fever. Has been used with some success for treating ankylosing spondylitis, gout and psoriatic arthritis. May reduce pain, fever and inflammation of pericarditis. May be used iv with opiates to relieve moderate to severe pain. Ibuprofen lysine may be used iv to treat patent ductus arteriosus (pda) in premature neonates
Adult Dose
Child Dose
Renal Dose
Administration
Contra Indications
Precautions
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Ibuprofen, Caffeine :
Mechanism of Action
The exact mechanism of action of ibuprofen is unknown. Ibuprofen is a non-selective inhibitor of cyclooxygenase, an enzyme invovled in prostaglandin synthesis via the arachidonic acid pathway. Its pharmacological effects are believed to be due to inhibition cylooxygenase-2 (cox-2) which decreases the synthesis of prostaglandins involved in mediating inflammation, pain, fever and swelling. Antipyretic effects may be due to action on the hypothalamus, resulting in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation. Inhibition of cox-1 is thought to cause some of the side effects of ibuprofen including gi ulceration. Ibuprofen is administered as a racemic mixture. The r-enantiomer undergoes extensive interconversion to the s-enantiomer in vivo. The s-enantiomer is believed to be the more pharmacologically active enantiomer
Note
PROFINAL XP "400mg, 65mg" Tablets / Film-coated manufactured by Julphar (Gulf Pharmaceutical Industries). Its generic name is Ibuprofen, Caffeine. PROFINAL XP is availble in United Arab Emirates.
Farmaco UAE drug index information on PROFINAL XP Tablets / Film-coated is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.