Rapamune Tablets / Sugar-coated
Sirolimus
1mg
Pfizer Europe MA EEIG
| Pack size | 30's (10's Blister x 3) |
|---|---|
| Dispensing mode | POM |
| Source | BELGIUM |
| Agent | Modern Pharmaceutical Co. |
| Retail Price | 696.00 AED |
Indications
Rapamune Tablets / Sugar-coated is used for:
For the prophylaxis of organ rejection in patients receiving renal transplants.
Adult Dose
Child Dose
Renal Dose
Administration
Contra Indications
Precautions
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Sirolimus :
Mechanism of Action
Sirolimus inhibits T lymphocyte activation and proliferation that occurs in response to antigenic and cytokine (Interleukin IL-2, IL-4, and IL-15) stimulation by a mechanism that is distinct from that of other immunosuppressants. Sirolimus also inhibits antibody production. In cells, sirolimus binds to the immunophilin, FK Binding Protein-12 (FKBP-12), to generate an immunosuppressive complex. The sirolimus:FKBP-12 complex has no effect on calcineurin activity. This complex binds to and inhibits the activation of the mammalian Target Of Rapamycin (mTOR), a key regulatory kinase. This inhibition suppresses cytokine-driven T-cell proliferation, inhibiting the progression from the G1 to the S phase of the cell cycle.
Note
Rapamune 1mg Tablets / Sugar-coated manufactured by Pfizer Europe MA EEIG. Its generic name is Sirolimus. Rapamune is availble in United Arab Emirates.
Farmaco UAE drug index information on Rapamune Tablets / Sugar-coated is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.