RECORMON Injection
Epoetin beta
5000 IU
F. Hoffmann-La Roche Ltd.
| Pack size | 5 Vials (Dry) + 5 Solvent Ampoules (1ml) |
|---|---|
| Dispensing mode | POM |
| Source | SWITZERLAND |
| Agent | IBN KHALDOON DRUG STORE |
| Retail Price | 2502.00 AED |
Available as:
Indications
RECORMON Injection is used for:
Anaemia of chronic renal failure, Anaemia in zidovudine-treated HIV-infected patients, Anemia related to non-myeloid malignant disease chemotherapy, To reduce the need for allogenic blood tranfusion, Anaemia of prematurity.
Adult Dose
Anemia Associated with Chronic Renal Failure
Do not increase dose more frequently than q4weeks; decreases in dose can occur more frequently; avoid frequent dose adjustments
If hemoglobin rises rapidly (e.g., > 1 g/dL in any 2-week period), reduce dose by 25% or more as needed to reduce rapid responses
For patients who do not respond adequately, if hemoglobin has not increased by >1 g/dL after 4 weeks of therapy, increase dose by 25%
Patients with chronic renal failure on dialysis
Dose if not currently on ESA therapy: 0.6 mcg/kg IV/SC q2week initially
Initiate treatment when hemoglobin level < 10 g/dL
If hemoglobin level approaches or exceeds 11 g/dL, reduce or interrupt dose
Once hemoglobin has been stabilized, Epoetin beta may be administered once monthly using a dose that is twice that of the every-two-week dose and subsequently titrated as necessary
Switching Patients Currently on Other ESA
Receiving epoetin <8000 units/week: 120 mcg/qmonth or 60 mcg/q2week IV/SC
Receiving epoetin 8000-16000 units/week: 200 mcg/qmonth or 100 mcg/q2week IV/SC
Receiving epoetin >16000 units/week:360 mcg/qmonth or 180 mcg/q2week IV/SC
Child Dose
Safety & efficacy not established
Renal Dose
Administration
Administration
IV route is recommended for patients receiving hemodialysis because IV route may be less immunogenic
SC: inject in abdomen, arm or thigh
Contra Indications
Uncontrolled hypertension. Neonates: injections containing benzyl alcohol.
Precautions
Hypertension, history of seizure, thrombocytosis, chronic hepatic impairment, ischaemic vascular disease, malignant tumours, epilepsy; recent MI or CVA. Fe deficiency, infection, inflammatory disorders, haemolysis and aluminium intoxication may decrease response to epoetin beta. Regularly monitor platelet counts and serum-potassium concentrations. Control haematocrit levels. Poorly-controlled hypertension: Monitor BP, Hb and electrolytes. Anaemia (eg, megaloblastic or folic acid): Give Fe supplements when needed. Thromobocytosis: monitor platelet count for 1st 8 wk. Lactation.
Lactation: not known if excreted in breast milk, use caution
Pregnancy-Lactation
Interactions
Antagonises the hypotensive effects of ACE inhibitors and angiotensin-II receptor antagonists and increases risk of hyperkalaemia
Adverse Effects
Side effects of Epoetin beta :
>10%
Hypertension (13%), Diarrhea (11%), Nasopharyngitis (11%)
1-10%
Headache (9%), Upper respiratory tract infection (9%), Cough (6%), Hypotension (5%), Urinary tract infection (5%), Procedural arteriovenous fistula thrombosis (5%)
Frequency Not Defined
Coronary artery disease, Anemia, Septic shock, Serious cardiovascular and thromboembolic events, Seizures, Immunogenicity related PRCA, Increased mortality and/or tumor progression in cancer patients, Increased mortality, Concomitant termination of other CRF therapy, Stevens-Johnson syndrome, Toxic epidermal necrolysis
Mechanism of Action
Epoetin beta stimulates RBC production in the bone marrows which transmits O2 through out the body.
Note
RECORMON 5000 IU Injection manufactured by F. Hoffmann-La Roche Ltd.. Its generic name is Epoetin beta. RECORMON is availble in United Arab Emirates.
Farmaco UAE drug index information on RECORMON Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.