Remeron Tablets / Film-coated

Mirtazapine
30mg
N.V. ORGANON
Pack size 30's (10's Blister x 3)
Dispensing mode POM
Source NETHERLANDS
AgentCITY MEDICAL STORE
Retail Price 170.00 AED

Indications

Remeron Tablets / Film-coated is used for: Depression, Major depressive disorder

Adult Dose

Oral Depression Adult: Initially, 15 mg daily; may be increased gradually depending on clinical response. Change dose at intervals of at least 1-2 wk. Usual effective dose: 15-45 mg daily given as single dose, preferably at bedtime, or in 2 divided doses. Elderly Depression 7.5 mg/day PO qHS; increase by 7.5-15 mg/day no more frequently than q1-2Weeks; not to exceed 45 mg/day Alzheimer Dementia-related Depression 7.5 mg/day PO qHS; increase by 7.5-15 mg/day no more frequently than q1-2Weeks; not to exceed 60 mg/day Hepatic impairment: Clearance is reduced; monitor closely

Child Dose

Safety and efficacy not established

Renal Dose

Renal impairment (CrCl <39 mL/min): Clearance is reduced; monitor closely

Administration

May be taken with or without food.

Contra Indications

Mirtazapine Tablets are contraindicated in patients with a known hypersensitivity to mirtazapine or to any of the excipients.

Precautions

Epilepsy or history of seizures; avoid completely in unstable cases. Hepatic or renal impairment, cardiac disorders e.g. conduction disturbances, angina pectoris, recent MI. Hypotension, DM, psychoses, history of bipolar disorder. Stop treatment if jaundice develops. Micturition disturbances, angle-closure glaucoma, raised intraocular pressure. Monitor patient for signs of bone marrow depression. Monitor patient for suicidal tendency. Avoid abrupt withdrawal. May impair ability to drive or operate machinery. Pregnancy and lactation. Elderly. Lactation: Avoid

Pregnancy-Lactation

Pregnancy There are no adequate and well-controlled studies in pregnant women Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed Animal studies Reproduction studies in pregnant rats and rabbits at doses up to 100 mg/kg and 40 mg/kg, respectively (20 and 17 times the maximum recommended human dose [MRHD] on an mg/m2 basis, respectively), have revealed no evidence of teratogenic effects However, in rats, there was an increase in postimplantation losses in dams treated with mirtazapine Lactation May be excreted in breast milk; caution advised

Interactions

Potentiation of sedative effects with alcohol or benzodiazepines. Increased plasma levels with potent CYP3A4 inhibitors (e.g. HIV-protease inhibitors, azole antifungals including ketoconazole, erythromycin, nefazodone). Reduced plasma levels with carbamazepine and other inducers of CYP3A4. Increased bioavailability with cimetidine. Potentially Fatal: Do not use with or within 2 wk of stopping an MAOI; at least 1 wk should elapse between discontinuing mirtazapine and initiating any drug which may provoke a serious reaction (e.g. phenelzine).

Adverse Effects

Side effects of Mirtazapine : >10% Somnolence (54%), Weight gain (>7% increase in <49% of pediatric patients), Xerostomia (25%), Increased appetite (17%), Constipation (13%) 1-10% Asthenia (8%), lWeakness (8%), Weight gain (>7% increase in 8% of adults), Dizziness (7%), Serum TGs increased (6%), Dream disorder (4%), Disturbance in thinking (3%), ALT increased (2%), Peripheral edema (2%), Myalgia (2%), Confusion (2%), Urinary frequency (2%), Tremor (2%), Back pain (2%), Dyspnea (1%) <1% Mania (0.2%), Grand mal seizure (less than 0.1%) Frequency Not Defined Depression exacerbation, Status epilepticus, Suicidal thoughts, suicide (rare), Agranulocytosis, Neutropenia

Mechanism of Action

Mirtazapine, a piperazinoazepine tetracyclic antidepressant, enhances noradrenergic and serotonergic activity through blockade of central presynaptic adrenergic alpha 2-receptors.

Note

Remeron 30mg Tablets / Film-coated manufactured by N.V. ORGANON. Its generic name is Mirtazapine. Remeron is availble in United Arab Emirates. Farmaco UAE drug index information on Remeron Tablets / Film-coated is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Mirtazapine :