SANDOSTATIN LAR Infusion

Octreotide
20mg
Novartis Pharma AG
Pack size 1 Vial (Dry) + 2 Vehicle Ampoule (2ml) + Syringe Set
Dispensing mode POM
Source SWITZERLAND
AgentCITY MEDICAL STORE
Retail Price 10530.00 AED

Indications

SANDOSTATIN LAR Infusion is used for: Acromegaly, Variceal haemorrhage, Secretory neoplasms, Following pancreatic surgery, HIV-associated diarrhoea

Adult Dose

Acromegaly Solution: 50 mcg SC q8hr initially; titrate up to 500 mcg SC q8hr if necessary; after successful treatment with solution for 2 weeks, initiate treatment with suspension (depot injection) Suspension (depot injection): 20 mg IM (gluteal) every 4 weeks for 3 months; titrate up or down to 10-30 mg IM every 4 weeks, depending on response; not to exceed 40 mg, as follows Symptoms controlled: If GH < 1 ng/mL and IGF-1 normal, decrease dose to 10 mg IM every 4 weeks; if GH < 2.5 ng/mL and IGF-1 normal, maintain dose at 20 mg IM every 4 weeks Symptoms uncontrolled: If GH > 2.5 ng/mL or IGF-I elevated, increase dose to 30 mg IM every 4 weeks; if symptoms persist, increase to 40 mg IM Carcinoid Tumor Solution: 100-600 mcg/day SC divided q6-12hr; may titrate to 1500 mcg/day; after successful treatment with solution for 2 weeks, initiate treatment with suspension (depot injection) Suspension (depot injection): 20 mg IM every 4 weeks if regular injection well tolerated Subcutaneous Prophylaxis of complications following pancreatic surgery Adult: 100 mcg tid of a rapid-acting preparation given for 7 consecutive days, starting at least 1 hr before operation. HIV-associated diarrhoea Adult: Initial dose 100 mcg tid. If symptoms are not controlled after 1 wk, increase dose to 500 mcg tid. Intravenous Variceal haemorrhage in patients with cirrhosis Adult: As continuous IV infusion: 25 mcg/hr for 48 hr (up to 5 days in patients at high risk of re-bleeding). Hepatic impairment: Cirrhosis, 10 mg IM every 4 weeks initially, then titrate to effect

Child Dose

Safety and efficacy not established

Renal Dose

Renal impairment: Without dialysis, dose adjustment not necessary; with dialysis, 10 mg IM every 4 weeks initially, then titrate to effect

Administration

IV Preparation Common diluent: 50-100 ?g/50 mL NS Common diluent for continuous IV infusion: 1200 ?g/250 mL NS Minimum volume: 50 mL NS IV/IM Administration IM Administer suspension (depot injection) immediately after reconstitution; inject into gluteal muscle, avoiding deltoid IV IV administration may be IVP, IVPB, or continuous infusion Regular injection only: IVP should be administered undiluted over 3 minutes IVPB: Administer over 15-30 minutes Continuous infusion: 25-50 ?g/hr for treatment of esophageal variceal bleeding

Contra Indications

Hypersensitivity.

Precautions

Renal disease; risk of gall bladder disease; DM; hypothyroidism. Pregnancy, lactation, children, elderly. Monitor levels of vitamin B12 during long term therapy. Lactation: Whether octreotide crosses into breast milk is not known; avoid giving to lactating women

Pregnancy-Lactation

Interactions

Dosage adjustment of concurrent therapy may be necessary with calcium channel blockers, oral hypoglycaemics, ?-blockers, diuretics. May increase concentration of bromocriptine. Potentially Fatal: Requirements of insulin may be reduced requiring careful blood-glucose monitoring. Reduction in ciclosporin bioavailability and efficacy.

Adverse Effects

Side effects of Octreotide : >10% Gallbladder problems (>60%): Decreased gallbladder contractility, gallstones, cholecystitis, cholestatic hepatitis, Dysglycemia (25%), Hypothyroidism (25%), Bradycardia (25%) 1-10% ECG changes (10%), Arrhythmia (9%), Pancreatitis, Upper respiratory tract infection, Fatigue, Headache, Malaise, Rash, Diarrhea, Nausea, Vomiting, Pain at injection site, Joint pain, Blurred vision

Mechanism of Action

Octreotide is a synthetic analogue of somatostatin which acts by suppressing basal and stimulated secretion of growth hormone (GH). It also suppresses LH response to gonadotrophin-releasing hormone and reduces the secretion of gastrin, vasoactive intestinal peptide (VIP), insulin, glucagon, secretin, motilin and pancreatic polypeptide.

Note

SANDOSTATIN LAR 20mg Infusion manufactured by Novartis Pharma AG. Its generic name is Octreotide. SANDOSTATIN LAR is availble in United Arab Emirates. Farmaco UAE drug index information on SANDOSTATIN LAR Infusion is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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