Saventrine Injection
Isoproterenol (Isoprenaline)
1mg/ml
PHARMAX LTD.
| Pack size | 2ml Ampoule x 10 |
|---|---|
| Dispensing mode | POM |
| Source | UK |
| Agent | AL HAYAT PHARMACEUTICALS |
| Retail Price | 35.50 AED |
Available as:
Indications
Saventrine Injection is used for:
Adams-Stokes Attacks, Cardiac Arrest, Heart Block
Adult Dose
Intravenous
Adams-Stokes Attacks, Cardiac Arrest, or Heart Block
IV bolus: 0.02-0.06 mg (1-3 mL of a 1:50,000 dilution), initially, THEN doses of 0.01-0.2 mg
IV infusion: 5 mcg/min (1.25 mL of a 1:250,000 dilution), initially, THEN doses of 2-20 mcg/min based on patient's response
Shock
0.5-5 mcg/min (0.25-2.5 mL of a 1:250,000 dilution) IV infusion
Bronchospasm During Anesthesia
0.01-0.02 mg IV repeat PRN
Child Dose
Renal Dose
Administration
IV/IM Administration
Adminster by IV infusion (requires infusion pump), or
By direct IV, IM, or SC injection
In extreme emergencies, by intracardiac injection
IV Preparation
1 mg (5 mL) in 500 mL D5W (2 mcg/mL) for IV infusion
Contra Indications
Angina pectoris; ventricular arrythmias requiring inotropic therapy; tachyarrhythmias; recent MI; tachycardia; heart block due to cardiac glycoside intoxication.
Precautions
Patient with CV disease (e.g. coronary artery disease, ischaemic heart disease), hypertension, diabetes mellitus, distributive shock, hyperthyroidism, aneurysms. May exacerbate Adams-Stokes seizures during normal sinus rhythm or transient heart block. Ensure adequate ventilation. Renal and hepatic impairment. Elderly. Pregnancy and lactation. Patient Counselling This drug may cause dizziness, if affected, do not drive or operate machinery. Monitoring Parameters Monitor blood pressure, heart rate, urine flow, ECG, central venous pressure, blood gases. Monitor acid-base balance and correct any electrolyte disturbances.
Pregnancy-Lactation
Pregnancy Category: C
Lactation: not known if excreted into breast milk, avoid
Interactions
Enhanced arrhythmogenic effect with inhalational anaesthetics (e.g. halothane and cyclopropane). Antagonistic effects with β-adrenergic blocking agents (e.g. propranolol, atenolol). Increased risk of cardiac arrhythmias with levodopa. May reduce antianginal effects of nitrates. Magnified effect with MAOIs and chlorpromazine.
Potentially Fatal: Severe arrhythmias with epinephrine and digitalis. Additive cardiotoxic properties and potential myocardial necrosis with IV methyl xanthines (e.g. aminophylline and theophylline) and IV corticosteroids.
Adverse Effects
Side effects of Isoproterenol (Isoprenaline) :
Frequency Not Defined
Tachycardia
Hypertension
Dysrhythmias
Angina
Dizziness
Nervousness
Restlessness
Hypokalemia
MI size increased
Syncope
Confusion
Headache
Tremor
Nausea
Vomiting
Weakness,
Tremor
Dyspnea
Pulmonary edema
Diaphoresis
Blurred vision
Mechanism of Action
Strong beta-1 & beta-2 effects resulting in relaxation of GI, bronchial, and uterine smooth muscle; may increase vasodilation of peripheral vasculature, and heart rate and contractility
Note
Saventrine 1mg/ml Injection manufactured by PHARMAX LTD.. Its generic name is Isoproterenol (Isoprenaline). Saventrine is availble in United Arab Emirates.
Farmaco UAE drug index information on Saventrine Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.