SIMULECT IV Injection
Basiliximab
20mg
Novartis Pharma AG
| Pack size | 1 Vial (Powder) + 1 Solvent Ampoule (5ml) |
|---|---|
| Dispensing mode | POM |
| Source | SWITZERLAND |
| Agent | CITY MEDICAL STORE |
| Retail Price | 6974.50 AED |
Indications
SIMULECT IV Injection is used for:
Acute graft rejection in renal transplantation
Adult Dose
Intravenous
Prophylaxis of Renal Transplant Rejection
20 mg IV within 2 hr prior to transplant surgery, THEN
20 mg IV 4 days after transplant
Used in regimen containing cyclosporine and corticosteroids
Child Dose
Prophylaxis of Renal Transplant Rejection
>35 kg: Administer as in adults; 20 mg IV within 2 hr prior to transplant surgery, THEN, 20 mg IV 4 days after transplant
<35 kg: 10 mg IV within 2 hr prior to transplant surgery, THEN 10 mg IV 4 days after transplant
Used in regimen containing cyclosporine and corticosteroids
Renal Dose
Administration
IV Preparation
Reconstitute vials with 5 mL SWI
Dilute reconstituted contents in 50 mL NS or D5W
IV Administration
For central or intravenous administration only
Infuse over 20-30 min
Contra Indications
Hypersensitivity to basiliximab and murine proteins.
Precautions
Pregnancy and lactation. Re-exposure to a subsequent course of therapy of basiliximab.
Lactation: Unknown whether excreted in milk; because of the potential for adverse reactions, a decision should be made to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother
Pregnancy-Lactation
Pregnancy Category: B
Lactation: Unknown whether excreted in milk; because of the potential for adverse reactions, a decision should be made to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother
Interactions
Immunosuppressives other than ciclosporin and corticosteroids may increase the potential for over-immunosuppression.
Adverse Effects
Side effects of Basiliximab :
Peripheral oedema, hypertension, atrial fibrillation; fever, headache, insomnia, pain; wound complication, acne; hypokalaemia, hyperglycaemia, hyperuricaemia, hypophosphataemia, hypercholesterolaemia; GI effects; UTI; anaemia; tremor; dyspnoea, infection.
Rarely, hypersensitivity and anaphylactoid-type reactions.
Mechanism of Action
Basiliximab, a chimeric murine/human monoclonal antibody, blocks the ?-chain of the interleukin-2 receptor complex on the surface of activated T-lymphocytes.
Note
SIMULECT IV 20mg Injection manufactured by Novartis Pharma AG. Its generic name is Basiliximab. SIMULECT IV is availble in United Arab Emirates.
Farmaco UAE drug index information on SIMULECT IV Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.