Sine-Up Syrup
Chlorpheniramine + Phenylephrine
"2.5mg, 5mg/5ml"
Pharco Pharmaceuticals
| Pack size | 120ml Plastic Bottle |
|---|---|
| Dispensing mode | POM |
| Source | EGYPT |
| Agent | GULF DRUG EST. |
| Retail Price | 6.50 AED |
Indications
Sine-Up Syrup is used for:
Nasal Congestion, Sneezing, Common Cold, Hay Fever, Allergic Rhinitis
Adult Dose
Nasal Congestion or Sneezing Due to Common Cold, Hay Fever, Allergic Rhinitis
1 tablet PO q4hr; not to exceed 6 tab/24h
Child Dose
Nasal Congestion or Sneezing Due to Common Cold, Hay Fever, Allergic Rhinitis
>12 Years Old
1 tablet PO q4hr; not to exceed 6 tab/24 hr
Renal Dose
Administration
Contra Indications
Contraindicated in documented hypersensitivity; asthma attacks, narrow-angle glaucoma, symptomatic prostate hypertrophy, bladder-neck obstruction, and stenosing peptic ulcer
Precautions
Caution in elderly patients, hyperthyroidism, myocardial disease, bradycardia, partial heart block or severe arteriosclerosis when administering phenylephrine; in hypovolemia, phenylephrine use is not a substitute for replacement of blood, fluids and electrolytes, and plasma (promptly restore with loss); dilute IV and administer via large vein; extravasation precautions required
Chlorpheniramine may cause significant confusional symptoms; not for administration to premature or full-term neonates
Lactation: excretion in milk unknown/contraindicated
Pregnancy-Lactation
Pregnancy Category: C
Lactation: excretion in milk unknown/contraindicated
Interactions
Adverse Effects
Side effects of Chlorpheniramine + Phenylephrine :
Hypertension, Hypotension, Palpitations, Reflex tachycardia, Severe peripheral and visceral vasoconstriction, Tachycardia, Confusion, Depression, Distress, Dizziness, Excitability, Euphoria, Fatigue, Headache, Insomnia, Irritability, Restlessness, Sedation, Tremor, Anorexia, Agranulocytosis, Hemolytic anemia, Thrombocytopenia, Thickening of bronchial secretions, Wheezing
Mechanism of Action
Chlorpheniramine blocks muscle responses in histamine and acts as an antagonism of the constrictor effects of histamine on respiratory smooth muscle.
Phenylephrine is a vasoconstrictor and a decongestant that relieves symptoms resulting from irritation of upper respiratory tract tissue. It shrinks swollen mucous membranes, reduces nasal congestion and tissue hyperemia.
Note
Sine-Up "2.5mg, 5mg/5ml" Syrup manufactured by Pharco Pharmaceuticals. Its generic name is Chlorpheniramine + Phenylephrine. Sine-Up is availble in United Arab Emirates.
Farmaco UAE drug index information on Sine-Up Syrup is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.