Skinoren 20% Cream
Azelaic acid
200mg/g
BAYER HEALTHCARE AG
| Pack size | 30g Tube |
|---|---|
| Dispensing mode | POM |
| Source | ITALY |
| Agent | PHARMAWORLD |
| Retail Price | 33.00 AED |
Indications
Skinoren 20% Cream is used for:
For the topical treatment of mild-to-moderate inflammatory acne vulgaris.
Adult Dose
Child Dose
Renal Dose
Administration
Contra Indications
Precautions
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Azelaic acid :
Mechanism of Action
The exact mechanism of action of azelaic acid is not known. It is thought that azelaic acid manifests its antibacterial effects by inhibiting the synthesis of cellular protein in anaerobic and aerobic bacteria, especially Staphylococcus epidermidis and Propionibacterium acnes. In aerobic bacteria, azelaic acid reversibly inhibits several oxidoreductive enzymes including tyrosinase, mitochondrial enzymes of the respiratory chain, thioredoxin reductase, 5-alpha-reductase, and DNA polymerases. In anaerobic bacteria, azelaic acid impedes glycolysis. Along with these actions, azelaic acid also improves acne vulgaris by normalizing the keratin process and decreasing microcomedo formation. Azelaic acid may be effective against both inflamed and noninflamed lesions. Specifically, azelaic acid reduces the thickness of the stratum corneum, shrinks keratohyalin granules by reducing the amount and distribution of filaggrin (a component of keratohyalin) in epidermal layers, and lowers the number of keratohyalin granules.
Note
Skinoren 20% 200mg/g Cream manufactured by BAYER HEALTHCARE AG. Its generic name is Azelaic acid. Skinoren 20% is availble in United Arab Emirates.
Farmaco UAE drug index information on Skinoren 20% Cream is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.