Staril Tablets
Fosinopril Sodium
20mg
BRISTOL - MYERS SQUIBB S.p.A. (ANAGNI)
| Pack size | 14's Blister |
|---|---|
| Dispensing mode | POM |
| Source | ITALY |
| Agent | Modern Pharmaceutical Co. |
| Retail Price | 50.00 AED |
Indications
Staril Tablets is used for:
Hypertension, Congestive heart failure
Adult Dose
Oral
Hypertension
Adult: Initially, 10 mg once daily, 1st dose given at bedtime to avoid precipitous fall in BP. Maintenance: 10-40 mg once daily.
Heart failure
Adult: Initially, 10 mg once daily, may increase to max 40 mg once daily. Patients at high risk of hypotension: Initially, 5 mg once daily.
Elderly: No dosage adjustment needed.
Child Dose
Oral
Hypertension
Child: <50 kg: Limited data suggests 0.1-0.6 mg/kg PO qDay
>50 kg: 5-10 mg PO qDay initially, not to exceed 40 mg/day
Renal Dose
Renal impairment: Moderate to severe: Initially, 5 mg once daily.
Administration
Should be taken on an empty stomach. Best taken 1 hr before meals. May be taken w/ meals to reduce GI discomfort.
Contra Indications
Hypersensitivity, idiopathic or hereditary angioedema, history of angioedema related to previous treatment with an ACE inhibitor. Bilateral renal artery stenosis. Pregnancy (2nd and 3rd trimesters), lactation.
Precautions
Severely impaired renal function; hyperkalaemia, hypovolaemia, collagen vascular diseases, valvular stenosis; before, during or immediately after anaesthesia, unilateral renal artery stenosis.
Lactation: excreted in breast milk; not recommended
Pregnancy-Lactation
Pregnancy Category: D
Discontinue as soon as pregnancy detected; during the second and third trimesters of pregnancy, drugs that act directly on the renin-angiotensin have been associated with fetal injury that includes hypotension, neonatal skull hypoplasia, anuria, reversible or irreversible renal failure, and death
Lactation: excreted in breast milk; not recommended
Interactions
Additive hyperkalaemic effect w/ K-sparing diuretics and K supplements. May increase lithium serum levels and toxicity. May decrease serum level w/ antacids. May increase risk of renal function deterioration w/ NSAIDs. May increase nitritoid reactions of gold (Na aurothiomalate).
Adverse Effects
Side effects of Fosinopril Sodium :
>10%
Dizziness (1.6-11.9%)
1-10%
Cough (2.2-9.7%), Headache (3.2%), Hyperkalemia (2.6%), Diarrhea (2.2%), Orthostatic hypotension (1.4-1.9%), Fatigue (1-2%)
Frequency Not Defined
Angioedema, ARF if renal artery stenosis, Aplastic anemia, Neutropenia, Arthralgia, Interstitial nephritis, Vasculitis, Rash.
Potentially Fatal: Cerebrovascular accident, rhythm disturbances, palpitations, hypotension, syncope, rashes, oedema, hypersensitivity reactions, angioedema.
Mechanism of Action
Fosinopril, a prodrug of fosinoprilat, competitively inhibits ACE from converting angiotensin I to angiotensin II resulting in decreased levels of angiotensin II which causes increased plasma renin activity and reduced aldosterone secretion. It also reduces Na and water retention. This promotes vasodilation and BP reduction.
Note
Staril 20mg Tablets manufactured by BRISTOL - MYERS SQUIBB S.p.A. (ANAGNI). Its generic name is Fosinopril Sodium. Staril is availble in United Arab Emirates.
Farmaco UAE drug index information on Staril Tablets is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.