Stocrin Tablets / Film-coated
Efavirenz
600mg
Merck Sharp & Dohme B.V.
| Pack size | 30's Plastic Bottle |
|---|---|
| Dispensing mode | POM |
| Source | NETHERLANDS |
| Agent | CITY MEDICAL STORE |
| Retail Price | 1713.50 AED |
Indications
Stocrin Tablets / Film-coated is used for:
HIV infection
Adult Dose
Oral
HIV infection
Adult: Combined with other antiretrovirals: 600 mg once daily. Dosing at bedtime recommended during 1st 2-4 wk of therapy to improve tolerability.
Hepatic impairment
Mild (Child-Pugh Class A): Dose adjustment not necessary; use caution
Moderate-to-severe (Child Pugh Class B or C): Not recommended
Child Dose
Oral
HIV infection
Child: Combined with other antiretrovirals: >3 yr,
10-14 kg: 200 mg;
15-19 kg: 250 mg;
20-24 kg: 300 mg;
25-32.4 kg: 350 mg;
32.5-39 kg: 400 mg;
>40 kg: 600 mg.
To be taken once daily.
Renal Dose
Renal impairment: No dosage adjustment needed
Administration
Should be taken on an empty stomach. Take on an empty stomach, preferably at bedtime.
Contra Indications
Severe hepatic impairment; hypersensitivity; lactation.
Precautions
Mild to moderate liver disease; renal impairment. Monitor liver enzymes and cholesterol. Discontinue if severe skin rash or fever develops; known or suspected hepatitis B or infection. History of mental illness or seizures; elderly. Pregnancy. Children.
Lactation: It is not known whether efavirenz is excreted in milk. It should not be administered to nursing mothers. The CDC advises HIV-infected women not to breast-feed to avoid postnatal transmission of HIV.
Pregnancy-Lactation
Pregnancy Category: D
Lactation: Unknown if distributed in human milk; the CDC advises HIV-infected women not to breastfeed to avoid postnatal transmission of HIV
Interactions
Hormonal contraceptives; antibacterial e.g. rifampicin, rifabutin, clarithromycin; enzyme inducers. St. John's wort may decrease serum level. Ethanol (hepatic and CNS adverse effects).
Potentially Fatal: Life-threatening adverse effects when used with terfenadine, astemizole, cisapride, midazolam, triazolam and ergot alkaloids.
Adverse Effects
Side effects of Efavirenz :
>10%
Total cholesterol increased (20-40%), Diarrhea (3-14%, children up to 39%), HDL increased (25-35%), Dizziness (28.1%), Rash (5-26%), Fever (children 21%), Depression (19%), Insomnia (16.3%), Cough (children 16%), Vomiting (3-12%), Anxiety (2-13%), Nausea (2-12%)
1-10%
Neutropenia (2-10%), Pruitis (9%), Impaired concentration (8.3%), Transaminases increased (2-8%), Somnolence (7.0%), Abnormal dreams (6.2%), Amylase increased (6%), Hyperglycemia (2-5%), Dyspepsia (4%), Abdominal pain (2-3%), Anorexia (2%), Hallucinations (1.2%)
Mechanism of Action
Efavirenz, a non-nucleoside reverse transcriptase inhibitor with activity against HIV, blocks the RNA-dependent and DNA-dependent polymerase activities including HIV replication.
Note
Stocrin 600mg Tablets / Film-coated manufactured by Merck Sharp & Dohme B.V.. Its generic name is Efavirenz. Stocrin is availble in United Arab Emirates.
Farmaco UAE drug index information on Stocrin Tablets / Film-coated is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.