Synvisc Hylan G - F 20 Injection / Intraarticular

Sodium Hyaluronate
10mg/ml
GENZYME BIOSURGERY
Pack size 2ml Syringe x 3
Dispensing mode POM
Source USA
AgentGULF DRUG EST.
Retail Price 1268.00 AED

Available as:

8mg/ml - Injection / Intraarticular

Indications

Synvisc Hylan G - F 20 Injection / Intraarticular is used for: Osteoarthritis

Adult Dose

Intra-articular Adult: Osteoarthritis of Knee Indicated for treatment of pain in osteoarthritis of the knee Inject 20 mg (2 mL) once wkly for 3-5 weeks.

Child Dose

Safety & efficacy not established

Renal Dose

Administration

Contra Indications

Hypersensitivity to sodium hyaluronate or avian proteins. Intra-articular injections are contraindicated in cases of past and present infections or skin diseases in the area of the injection site.

Precautions

Use caution when injecting Sodium Hyaluronate into patients who are allergic to avian proteins, feathers, and egg products. Strict aseptic administration technique must be followed. Remove joint effusion, if present, before injecting Sodium Hyaluronate. Do not use the same syringe for removing joint effusion and for injecting Sodium Hyaluronate. It is recommended that the patient avoid any strenuous activities or prolonged (i.e., more than 1 hour) weight-bearing activities such as jogging or tennis within 48 hours following the intra-articular injection. Lactation: Unknown whether distributed in breast milk, caution advised

Pregnancy-Lactation

Pregnancy Category: N/A Lactation: Not known if excreted in breast milk; not recommended

Interactions

The safety and effectiveness of the use of sodium hyaluronate concomitantly with other intra-articular injection has not yet been established. As sodium hyaluronate is precipitated by quaternary amine bactericides or disinfectants eg, benzalkonium chloride and chlorhexidine, etc, adequate attention should be given.

Adverse Effects

Side effects of Sodium Hyaluronate : >10% Arthralgia (25%), Tenderness (61-92%), Swelling (81-91%), Firmness (88-89%), Bruising (52-87%), Pruritus (25-36%), Skin discoloration (33-78%), Firmness (86-89%), Lumps/bumps (56-83%) 1-10% Increased blood pressure (4%), Fatigue (1%), Nausea (<2%), Injection site pain (3%), Paresthesia (1%), Tendonitis (2%), Limb pain (1%), Tendonitis (2%), Joint effusion (2%) <1% Angioedema, Arthritis, Herpetic eruptions, Thrombocytopenia, Peripheral edema, Vasovagal reaction, Hives, Gait disturbances

Mechanism of Action

Sodium hyaluronate is a polysaccharide which functions as a tissue lubricant. It is widely used in ophthalmic surgery because it forms a viscoelastic solution in water which makes it a suitable substitute for aqueous and vitreous humour.

Note

Synvisc Hylan G - F 20 10mg/ml Injection / Intraarticular manufactured by GENZYME BIOSURGERY. Its generic name is Sodium Hyaluronate. Synvisc Hylan G - F 20 is availble in United Arab Emirates. Farmaco UAE drug index information on Synvisc Hylan G - F 20 Injection / Intraarticular is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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