Tanexel Tablets / Film-coated
Exemestane
25mg
Hexal AG
| Pack size | 30's (10's Blister x 3) |
|---|---|
| Dispensing mode | POM |
| Source | GERMANY |
| Agent | ALPHAMED CO. (AUH) LTD. |
| Retail Price | 199.00 AED |
Indications
Tanexel Tablets / Film-coated is used for:
Breast cancer in postmenopausal women
Adult Dose
Oral
Advanced or locally advanced breast cancer
Adult: In women who are no longer responsive to anti-oestrogen therapy: 25 mg once daily.
Child Dose
Renal Dose
Administration
Should be taken with food. Take after a meal.
Contra Indications
Hypersensitivity. Premenopausal women. Pregnancy and lactation.
Precautions
Hepatic and renal impairment. Monitor bone mineral density at regular intervals especially in patients at risk of osteoporosis.
Lactation: Excretion in milk unknown; because of potential for serious adverse reactions in breast-fed infants, advise women not to breastfeed during treatment and for 1 month after final dose
Pregnancy-Lactation
Pregnancy Category: X
Lactation: Excretion in milk unknown; because of potential for serious adverse reactions in breast-fed infants, advise women not to breastfeed during treatment and for 1 month after final dose
Interactions
May result in reduced plasma levels of exemestane when used with CYP3A4 enzyme inducers. Oestrogen-containing drugs; St. John's wort, black cohosh, dong quai.
Adverse Effects
Side effects of Exemestane :
>10%
Fatigue (22%), Nausea (18%), Hot flashes (13%), Depression (13%), Pain (13%), Insomnia (11%)
1-10%
Anxiety (10%), Dyspnea (10%), Dizziness (8%), Headache (8%), Edema (7%), Vomiting (7%), Flu-like syndrome (6%), Abdominal pain (6%), Anorexia (6%), Cough (6%), Hypertension (5%), Constipation (5%), Diarrhea (4%)
<1%
Cardiac failure, Uterine polyps, Endometrial hyperplasia, Gastric ulcer
Frequency not defined
Hepatitis, Visual disturbances
Mechanism of Action
Exemestane is an irreversible selective aromatase inhibitor which acts as a false substrate for the aromatase enzyme, forming an intermediate that binds irreversibly to the active site causing its inactivation. It also lowers circulating oestrogens in estrogen-dependent breast carcinoma.
Note
Tanexel 25mg Tablets / Film-coated manufactured by Hexal AG. Its generic name is Exemestane. Tanexel is availble in United Arab Emirates.
Farmaco UAE drug index information on Tanexel Tablets / Film-coated is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.