TELFAST D 60/120mg Tablets / Extended Release

Fexofenadine Hydrochloride + Pseudoephedrine Hydrochloride
"60mg, 120mg"
SANOFI AVENTIS U.S. LLC
Pack size 10's Blister
Dispensing mode POM
Source USA
AgentCITY MEDICAL STORE
Retail Price 23.50 AED

Indications

TELFAST D 60/120mg Tablets / Extended Release is used for: Allergic rhinitis, Hay fever, Urticaria, Sneezing, Runny nose, Hives, Skin rash, Common cold, Allergy, Itchy or watery eyes, Nasal congestion

Adult Dose

Oral Seasonal Allergic Rhinitis with Nasal Congestion Adult: 1 tab 60 mg fexofenadine/120 mg pseudoephedrine PO BID

Child Dose

Child: >12 yr: 1 tab bid. <12 years: Safety and efficacy not established

Renal Dose

Renal Impairment Avoid

Administration

Take on empty stomach with water only Swallow whole; do not chew, crush, or split tablet

Contra Indications

Severe hypertension, phaeochromocytoma.

Precautions

Hyperthyroidism; ischaemic heart disease, arrhythmia or tachycardia; occlusive vascular disorders e.g. arteriosclerosis, hypertension or aneurysms; DM and closed-angle glaucoma; renal impairment, prostatic enlargement. Pregnancy; lactation. Lactation: avoid, not known if enters breast milk

Pregnancy-Lactation

Pregnancy Category: C Lactation: avoid, not known if enters breast milk

Interactions

Increased risk of hypertension and arrhythmias if given with cardiac glycosides, quinidine or TCAs. Increased risk of vasoconstrictor effects if given with ergot alkaloids or oxytocin. Co-admin with MAOIs may cause hypertensive crisis. Anaesthetics e.g. cyclopropane, halothane and other halogenated anaesthestics; antihypertensive agents.

Adverse Effects

Side effects of Fexofenadine Hydrochloride + Pseudoephedrine Hydrochloride : 1-10% Headache (7.2%), Drowsiness (1.3%), Fatigue (1.3%) Frequency Not Defined CNS depression, Sedation ranging from mild drowsiness to deep sleep (most frequent), Dizziness, Lassitude, Disturbed coordination, Muscular weakness, Restlessness, insomnia, tremors, euphoria, nervousness, delirium, palpitation, seizures is less common, Epigastric distress, Anorexia, Nausea, Vomiting, Diarrhea, Constipation, Cholestasis, hepatitis, hepatic failure, hepatic function abnormality, jaundice is rare, Tachycardia, palpitation ECG changes (eg, widened QRS). Arrhythmias (eg, extrasystole, heart block), Hypotension, Hypertension, Dizziness, sedation, and hypotension may occur in geriatric patients, Dryness of mouth, nose, and throat, Dysuria, Urinary retention, Impotence, Vertigo, Visual disturbances, Blurred vision, Diplopia; tinnitus, Acute labyrinthitis, Tremors, Nervousness, Irritability, Facial dyskinesia, Tightness of the chest, Thickening of bronchial secretions, Wheezing, Nasal stuffiness, Sweating, Chills, Early menses, Toxic psychosis, Faintness, Paresthesia, Agranulocytosis, Hemolytic anemia, Leukopenia, Thrombocytopenia, Pancytopenia, Dysmenorrhea, Dyspepsia, Fatigue, Ischemic colitis (pseudoephedrine)

Mechanism of Action

Fexofenadine, an active metabolite of terfenadine, is a competitive peripheral histamine H1-receptor antagonist on effector cells in the GI tract, blood vessels and respiratory tract. Pseudoephedrine is both an alpha-and beta-adrenergic receptor agonist. It causes vasoconstriction via direct stimulation of alpha-adrenergic receptors of the respiratory mucosa. It also directly stimulates beta-adrenergic receptors causing bronchial relaxation, increased heart rate and contractility.

Note

TELFAST D 60/120mg "60mg, 120mg" Tablets / Extended Release manufactured by SANOFI AVENTIS U.S. LLC. Its generic name is Fexofenadine Hydrochloride + Pseudoephedrine Hydrochloride. TELFAST D 60/120mg is availble in United Arab Emirates. Farmaco UAE drug index information on TELFAST D 60/120mg Tablets / Extended Release is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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