Ticlid Tablets / Film-coated
Ticlopidine Hydrochloride
250mg
Sanofi Winthrop Industrie
| Pack size | 20's (10's Blister x 2) |
|---|---|
| Dispensing mode | POM |
| Source | FRANCE |
| Agent | CITY MEDICAL STORE |
| Retail Price | 87.50 AED |
Indications
Ticlid Tablets / Film-coated is used for:
Hereditary hemorrhagic telangiectasia, Intermittent claudication, Ischaemic heart disease
Adult Dose
Oral
Prophylaxis of thrombotic stroke; Ischaemic heart disease; Intermittent claudication
Adult: >18 yr: 250 mg bid.
Prophylaxis of subacute stent occlusion after intracoronary stenting
Adult: >18 yr: 250 mg bid for 4 wk, in conjunction with aspirin, starting at the time of stent placement.
Hepatic impairment: Severe: contraindicated.
Child Dose
<18 years old: safety & efficacy not established
Renal Dose
Renal impairment: Dose reduction or discontinuance if haemorrhagic or haematopoietic complications occur.
Administration
Should be taken with food.
Contra Indications
Pre-existing or history of blood dyscrasias; haemostatic disorder or active pathological bleeding (eg. bleeding peptic ulcer, intracranial bleeding); severe hepatic dysfunction. Hypersensitivity. Lactation.
Precautions
Patients with increased risk of bleeding from trauma, surgery or pathological disorder. Moderate to severe renal impairment. May need to stop therapy 10-14 days before elective surgery. Full blood counts should be performed prior to therapy and every 2 wk during the first 3 mth of treatment. Pregnancy.
Lactation: not known whether excreted in breast milk, discontinue drug or do not nurse
Pregnancy-Lactation
Pregnancy Category: B
Lactation: not known whether excreted in breast milk, discontinue drug or do not nurse
Interactions
Reduced clearance with cimetidine; corticosteroid may antagonise effects on bleeding time. Avoid concurrent use with clopidogrel.
Potentially Fatal: Risk of haemorrhage increased with NSAIDs and oral anticoagulants; decreased metabolism of theophylline, phenytoin and bupropion.
Adverse Effects
Side effects of Ticlopidine Hydrochloride :
>10%
Diarrhea (12.5%)
1-10%
Elevated alkaline phosphatase (7.6%), Nausea (7%), Dyspepsia (7%), Rash (5%), GI pain (3.7%), Elevated AST/SGOT (3.1%), Neutropenia (2.4%), Purpura (2.2%), Vomiting (1.9%), Flatulence (1.5%), Pruritus (1.3%), Dizziness (1%), Abnormal LFTs (1%), Anorexia (1%)
<1%
Agranulocytosis, Aplastic anemia, Pancytopenia, TTP
Potentially Fatal: Neutropenia, agranulocytosis, thrombotic thrombocytopenic purpura and aplastic anaemia.
Mechanism of Action
Ticlopidine inhibits adenosine diphosphate-mediated platelet aggregation.
Note
Ticlid 250mg Tablets / Film-coated manufactured by Sanofi Winthrop Industrie. Its generic name is Ticlopidine Hydrochloride. Ticlid is availble in United Arab Emirates.
Farmaco UAE drug index information on Ticlid Tablets / Film-coated is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.