Tirotax Infusion

Cefotaxime
500mg
Sandoz GmbH
Pack size 1 Vial (Dry)
Dispensing mode POM
Source AUSTRIA
AgentARABIAN ETHICALS CO.
Retail Price 16.50 AED

Indications

Tirotax Infusion is used for: Pneumonia, Meningitis, Peritonitis, Pelvic inflammatory disease, Endometritis, Pelvic cellulitis, Gonorrhea, Skin and skin structure infections, Respiratory tract infections, Urinary tract infections, Bacteremia/Septicemia, Bone and/or joint infections

Adult Dose

Adult: Infections Caused by Susceptible Organisms Uncomplicated: 1 g IV or IM q12hr Moderate to severe: 1-2 g IV or IM q8hr More serious (bloodstream infection [septicemia]): 2 g IV q6-8hr Life-threatening: 2 g IV q4hr; not to exceed 12 g/day Surgical prophylaxis 1 g 30-90 mins before procedure. Gonorrhoea 0.5-1 g as a single dose.

Child Dose

Children: IV, IM 50–180 mg/kg/day q6–8h 200–225 mg/kg/day for meningitis q6h Neonates: The recommended dosage is 50 mg/kg/day in 2 to 4 divided doses. In severe infections 150-200 mg/kg/day in divided doses have been given.

Renal Dose

Renal impairment: Severe: After an initial loading dose of 1 g, half the daily dose w/o changing the frequency.

Administration

IV Preparation Intermittent injection: Reconstitute 1 or 2 g with 10 mL SWI Infusion: Reconstitute infusion bottles with 50 or 100 mL NS or D5W IM: Add 2 mL, 3 mL or 5 mL of sterile or bacteriostatic water for inj to a vial

Contra Indications

Hypersensitivity to cephalosporins.

Precautions

History of penicillin allergy; colitis; impaired renal function; pregnancy, lactation. Lactation: Drug enters breast milk; use with caution

Pregnancy-Lactation

Pregnancy category: B Lactation: Drug enters breast milk; use with caution

Interactions

Probenecid decreases cefotaxime elimination. Potentially Fatal: Nephrotoxicity with furosemide and aminoglycosides.

Adverse Effects

Side effects of Cefotaxime : Colitis, Elevated blood urea nitrogen (BUN) and creatinine, Elevated hepatic transaminases, Fever. Pain at inj site; hypersensitivity reactions, rash, pruritus; diarrhoea, nausea, vomiting; candidiasis; eosinophilia, neutropenia, leucopenia, thrombocytopenia. Potentially Fatal: Anaphylactic reaction; nephrotoxicity.

Mechanism of Action

Cefotaxime binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.

Note

Tirotax 500mg Infusion manufactured by Sandoz GmbH. Its generic name is Cefotaxime. Tirotax is availble in United Arab Emirates. Farmaco UAE drug index information on Tirotax Infusion is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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