Tobrin 0.3% Eye Drops (Solution)
Tobramycin Eye prep
3mg/ml
Egyptian International Pharmaceutical Industries Co. (E.I.P.I.Co.)
| Pack size | 5ml Plastic Dropper Bottle |
|---|---|
| Dispensing mode | POM |
| Source | EGYPT |
| Agent | PHARMATRADE |
| Retail Price | 7.50 AED |
Indications
Tobrin 0.3% Eye Drops (Solution) is used for:
Ocular infection, bacterial eye infection
Adult Dose
Ophthalmic
Ocular infections
Adult: As eye drop: Mild to moderate infections: Instill 1-2 drops into affected eye every 4 hr.
Severe infections: Instill 2 drops into affected eye every 30-60 minutes initially until improvement, reduce treatment frequency before discontinuation.
As eye ointment: Mild to moderate infections: Apply a half-inch ribbon bid-tid into affected eye.
Severe infections: Apply a half-inch ribbon into the affected eye every 3-4 hr until improvement, reduce treatment frequency before discontinuation.
Child Dose
Ophthalmic
Ocular infections
Child: >1 yr: As eye drop: Mild to moderate infections: Instill 1-2 drops into affected eye every 4 hr.
Severe infections: Instill 2 drops into affected eye every 30-60 minutes initially until improvement, reduce treatment frequency before discontinuation.
As eye ointment: Mild to moderate infections: Apply a half-inch ribbon bid-tid into affected eye.
Severe infections: Apply a half-inch ribbon into the affected eye every 3-4 hr until improvement, reduce treatment frequency before discontinuation.
Renal Dose
Administration
Contra Indications
This eye drop is contraindicated in epithelial herpes simplex keratitis (dendritic keratitis), vaccinia, varicella and other viral disease of the cornea and conjunctiva.It is contraindicated in mycobacterial infections of the eye caused by acid-fast bacilli such as Mycobacterium tuberculosis, Mycobacterium leprae, or Mycobacterium avium. Fungal diseases of eye, untreated purulent infection of the eye. Hypersensitivity to any component of the medication.
Precautions
May result in overgrowth of nonsusceptible organisms, including fungi. Patient Counselling This drug may cause temporary blurred vision, if affected, do not drive or operate machinery. Contact lens wear is not recommended during treatment
Lactation: Unknown whether drug is safe for nursing infants; discontinue, or do not nurse
Pregnancy-Lactation
Pregnancy category: B
Lactation: Unknown whether drug is safe for nursing infants; discontinue, or do not nurse
Interactions
Increased nephrotoxicity or ototoxicity with etacrynic acid, furosemide, other aminoglycosides, cefalotin, cisplatin, vancomycin, piperacillin, ciclosporin, amphotericin B. Decrease serum tobramycin levels with miconazole.
Potentially Fatal: Increased neuromuscular-blocking activity with magnesium and other neuromuscular-blocking agents.
Adverse Effects
Side effects of Tobramycin Eye prep :
Localized ocular toxicity and hypersensitivity, including increased lacrimation, itching and edema of eyelid, and conjunctival erythema (<3%)
Sensitivity reaction, punctate keratitis
Mechanism of Action
Tobramycin acts by binding to 30S ribosomal subunits thus interfering with bacterial protein synthesis. It is active against many aerobic gram-negative bacteria and some aerobic gram-positive bacteria but inactive against Chlamydia, fungi, viruses, and most anaerobic bacteria.
Note
Tobrin 0.3% 3mg/ml Eye Drops (Solution) manufactured by Egyptian International Pharmaceutical Industries Co. (E.I.P.I.Co.). Its generic name is Tobramycin Eye prep. Tobrin 0.3% is availble in United Arab Emirates.
Farmaco UAE drug index information on Tobrin 0.3% Eye Drops (Solution) is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.