Triaxone Infusion

Julphar (Gulf Pharmaceutical Industries)
Pack size 1 Vial (Dry) + 1 Solvent Ampoule (3.5ml)
Dispensing mode POM
Source UAE
Retail Price 58.50 AED


Triaxone Infusion is used for: Pneumonia, Meningitis, Acute otitis media, Lyme disease, Typhoid fever, Otitis media, Pelvic inflammatory disease, Septicemia, Skin and Skin-Structure Infections, Gonorrhea, Respiratory tract infections, Urinary tract infections, Bone and Joint Infections, Chlamydia infection, Surgical Prophylaxis

Adult Dose

Susceptible infections IV/IM 1-2 g/day, up to 4 g/day for severe infections. Intra-abdominal Infections Complicated, mild-to-moderate, community acquired: 1-2 g/day IV in single daily dose or divided q12hr for 4-7 days, in combination with metronidazole Meningitis 2 g IV q12hr for 7-14 days Acute Uncomplicated Pyelonephritis 1-2 g IV qDay Typhoid fever 2 g IV once daily for 14 days. Surgical Prophylaxis Prophylaxis of surgical infection 1 g IV 0.5-2 hours before procedure Uncomplicated Gonococcal Infections Uncomplicated gonococcal infection of pharynx, cervix, urethra, or rectum: ceftriaxone 250 mg IM once plus azithromycin 1 g PO once (preferred) or alternatively, doxycycline 100 mg PO q12hr for 7 days Pelvic Inflammatory Disease 250 mg IM as single dose with doxycycline, with or without metonidazole for 14 days

Child Dose

Children: IV, IM: 50–75 mg/kg/day, max 2 g/day q24h 50 mg/kg, max 1 g, 1–3 doses IM for AOM q24h 100 mg/kg/day for meningitis, max 4 g/day q12h

Renal Dose

Renal impairment: CrCl (ml/min) <10 Max: 2 g daily.


IV/IM Administration IV: Infuse intermittently over 30 minutes IM: Inject deep into large muscle mass

Contra Indications

Hypersensitivity to cephalosporins; hyperbilirubinaemic neonates. Do not use calcium or calcium-containing solutions or products with or within 48 hr of ceftriaxone administration due to risk of calcium-ceftriaxone precipitate formation.


History of penicillin allergy; severe renal impairment; pregnancy and lactation; superinfection. Lactation: Drug enters breast milk in low concentrations; use with caution


Pregnancy category: B Lactation: Drug enters breast milk in low concentrations; use with caution


May increase nephrotoxicity of aminoglycosides. May diminish therapeutic effect of BCG, typhoid vaccine, Na picosulfate. May increase anticoagulant effect of vit K antagonists (e.g. warfarin). May increase serum level w/ probenecid. Potentially Fatal: Admin w/ Ca-containing IV soln may cause precipitation of a crystalline material in the lungs and kidneys.

Adverse Effects

Side effects of Ceftriaxone : >10% Induration after IM injection (5-17%) 1-10% Eosinophilia (6%), Thrombocytosis (5%) , Diarrhea (3%), Elevated hepatic transaminases (3%), Leukopenia (2%), Rash (2%), Increased blood urea nitrogen (BUN) (1%), Induration at IV site (1%), Pain (1%) <1% Agranulocytosis, Anaphylaxis, Anemia, Basophilia, Bronchospasm, Candidiasis, Chills, Diaphoresis, Dizziness, Dysgeusia, Flushing, Gallstones, Glycosuria, Headache, Hematuria, Hemolytic anemia, Increased alkaline phosphatase or bilirubin, Increased creatinine, Jaundice, Leukocytosis, Lymphocytosis, Lymphopenia, Monocytosis, Nausea, Neutropenia, Phlebitis, Prolonged or decreased prothrombin time (PT), Pruritus, Renal stones, Serum sickness, Thrombocytopenia, Urinary casts, Vaginitis, Vomiting

Mechanism of Action

Ceftriaxone binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.


Triaxone 1g Infusion manufactured by Julphar (Gulf Pharmaceutical Industries). Its generic name is Ceftriaxone. Triaxone is availble in United Arab Emirates. Farmaco UAE drug index information on Triaxone Infusion is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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