TRIZIVIR Tablets / Film-coated
Abacavir (as sulphate), Lamivudine, Zidovudine
"300mg, 150mg, 300mg"
GLAXOSMITHKLINE PHARMACEUTICAL S.A.
| Pack size | 60's (12's Blister x 5) |
|---|---|
| Dispensing mode | POM |
| Source | POLAND |
| Agent | AL BAKER TRADING EST. |
| Retail Price | 2442.00 AED |
Indications
TRIZIVIR Tablets / Film-coated is used for:
ABACAVIR
For the treatment of HIV-1 infection, in combination with other antiretroviral agents. LAMIVUDINE
For the treatment of HIV infection and chronic hepatitis B (HBV). ZIDOVUDINE
Used in combination with other antiretroviral agents for the treatment of human immunovirus (HIV) infections.
For the treatment of HIV-1 infection, in combination with other antiretroviral agents. LAMIVUDINE
For the treatment of HIV infection and chronic hepatitis B (HBV). ZIDOVUDINE
Used in combination with other antiretroviral agents for the treatment of human immunovirus (HIV) infections.
Adult Dose
Child Dose
Renal Dose
Administration
Contra Indications
Precautions
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Abacavir (as sulphate), Lamivudine, Zidovudine :
Mechanism of Action
ABACAVIR
Abacavir is a carbocyclic synthetic nucleoside analogue and an antiviral agent. Intracellularly, abacavir is converted by cellular enzymes to the active metabolite carbovir triphosphate, an analogue of deoxyguanosine-5'-triphosphate (dGTP). Carbovir triphosphate inhibits the activity of HIV-1 reverse transcriptase (RT) both by competing with the natural substrate dGTP and by its incorporation into viral DNA. Viral DNA growth is terminated because the incorporated nucleotide lacks a 3'-OH group, which is needed to form the 5' to 3' phosphodiester linkage essential for DNA chain elongation. LAMIVUDINE
Lamivudine is a synthetic nucleoside analogue and is phosphorylated intracellularly to its active 5'-triphosphate metabolite, lamivudine triphosphate (L-TP). This nucleoside analogue is incorporated into viral DNA by HIV reverse transcriptase and HBV polymerase, resulting in DNA chain termination. ZIDOVUDINE
Zidovudine, a structural analog of thymidine, is a prodrug that must be phosphorylated to its active 5'-triphosphate metabolite, zidovudine triphosphate (ZDV-TP). It inhibits the activity of HIV-1 reverse transcriptase (RT) via DNA chain termination after incorporation of the nucleotide analogue. It competes with the natural substrate dGTP and incorporates itself into viral DNA. It is also a weak inhibitor of cellular DNA polymerase a and ?.
Abacavir is a carbocyclic synthetic nucleoside analogue and an antiviral agent. Intracellularly, abacavir is converted by cellular enzymes to the active metabolite carbovir triphosphate, an analogue of deoxyguanosine-5'-triphosphate (dGTP). Carbovir triphosphate inhibits the activity of HIV-1 reverse transcriptase (RT) both by competing with the natural substrate dGTP and by its incorporation into viral DNA. Viral DNA growth is terminated because the incorporated nucleotide lacks a 3'-OH group, which is needed to form the 5' to 3' phosphodiester linkage essential for DNA chain elongation. LAMIVUDINE
Lamivudine is a synthetic nucleoside analogue and is phosphorylated intracellularly to its active 5'-triphosphate metabolite, lamivudine triphosphate (L-TP). This nucleoside analogue is incorporated into viral DNA by HIV reverse transcriptase and HBV polymerase, resulting in DNA chain termination. ZIDOVUDINE
Zidovudine, a structural analog of thymidine, is a prodrug that must be phosphorylated to its active 5'-triphosphate metabolite, zidovudine triphosphate (ZDV-TP). It inhibits the activity of HIV-1 reverse transcriptase (RT) via DNA chain termination after incorporation of the nucleotide analogue. It competes with the natural substrate dGTP and incorporates itself into viral DNA. It is also a weak inhibitor of cellular DNA polymerase a and ?.
Note
TRIZIVIR "300mg, 150mg, 300mg" Tablets / Film-coated manufactured by GLAXOSMITHKLINE PHARMACEUTICAL S.A.. Its generic name is Abacavir (as sulphate), Lamivudine, Zidovudine. TRIZIVIR is availble in United Arab Emirates.
Farmaco UAE drug index information on TRIZIVIR Tablets / Film-coated is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.