Twinzol Sterile Ophthalmic Solution Ophthalmic solution

Dorzolamide 2% + Timolol 0.5% Eye prep

"20mg, 5mg/ml"

Orchidia Pharmaceutical Industries

Pack size	5ml Dropper Bottle
Dispensing mode	POM
Source	EGYPT
Agent	PHARMALINK
Retail Price	34.50 AED

Indications

Twinzol Sterile Ophthalmic Solution Ophthalmic solution is used for: Open-angle glaucoma, Ocular hypertension

Adult Dose

Ophthalmic Ocular hypertension; Open-angle glaucoma Adult: Instill 1 drop to the affected eye bid.

Child Dose

Ophthalmic Ocular hypertension; Open-angle glaucoma <2 years Contraindicated >2 years Instill 1 drop to the affected eye bid.

Renal Dose

Renal impairment: CrCl (ml/min) <30 Not recommended.

Administration

Contra Indications

Hypersensitivity to any of the components or sulphonamide. History or current bronchial asthma, severe COPD, sinus bradycardia, 2nd or 3rd degree AV block, overt cardiac failure, cardiogenic shock, CrClr <30 ml/min and hyperchloraemic acidosis.

Precautions

Hepatic impairment, mild to moderate renal impairment, children <2 yr. Avoid use in pregnancy and lactation. Prinzmetal's angina, cardiac disease, hypotension, myasthenia gravis, history of renal calculi, history of intra-ocular surgery, pre-existing chronic corneal defects. May worsen severe peripheral and central circulatory disorders. May mask symptoms of hypoglycaemia and hyperthyroidism. Withdraw gradually, especially in patients with coronary heart disease. Discontinue treatment at the first signs or symptoms of cardiac failure. Contact lenses to be removed before eyedrop application and wait at least 15 minutes before reinsertion. Apply other eyedrops 10 minutes apart. May affect ability to drive or operate machinery as it may cause blurred vision. Lactation: Excreted in breast milk; not recommended

Pregnancy-Lactation

Pregnancy Category: C Lactation: Excreted in breast milk; not recommended

Interactions

Additive hypotension and bradycardia with oral calcium channel blockers, catecholamine-depleting drugs or beta-blockers, antiarrhythmics (e.g. amiodarone), digitalis glycosides, parasympathomimetics, narcotics and MAOIs. Additive systemic side effects with oral carbonic anhydrase or beta-blockers; avoid concurrent use. Additive systemic beta-blockade with CYP2D6 inhibitors (e.g. quinidine, SSRIs) and timolol.

Adverse Effects

Side effects of Dorzolamide 2% + Timolol 0.5% Eye prep : >10% Dorzolamide Ocular burning, stinging, discomfort (33%), Bitter taste (25%), Superficial punctate keratitis (10-15%), Ocular allergic reactions (10%) Frequency Not Defined Dorzolamide, Blurred vision, Ocular dryness, Photophobia, Ocular redness, Tearing, Stevens-Johnson syndrome, Toxic epidermal necrolysis Timolol Arrythmia, Bradycardia, Syncope, Fatigue, Headache, Dyspnea, Bronchospasm, Chest pain, Edema, Paresthesia, Nausea, Rales, Depression, Decreased exercise tolerance, Raynaud's phenomenon Potentially Fatal: Cardiac failure, bronchospasm.

Mechanism of Action

Timolol maleate, a nonselective beta-adrenergic blocker, reduces aqueous humor formation. Dorzolamide, a carbonic anhydrase inhibitor, has actions similar to acetazolamide. By inhibiting carbonic anhydrase in the ciliary processes of the eye, dorzolamide decreases aqueous humor secretion. Used together, there is additional intraocular pressure reduction compared to using either component alone, but the reduction is not as much as concomitant admin of dorzolamide tid and timolol bid.

Note

Twinzol Sterile Ophthalmic Solution "20mg, 5mg/ml" Ophthalmic solution manufactured by Orchidia Pharmaceutical Industries. Its generic name is Dorzolamide 2% + Timolol 0.5% Eye prep. Twinzol Sterile Ophthalmic Solution is availble in United Arab Emirates. Farmaco UAE drug index information on Twinzol Sterile Ophthalmic Solution Ophthalmic solution is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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