Uroquad Tablets

Allopurinol

300mg

BOEHRINGER MANNHEIM GmbH

Pack size	100's
Dispensing mode	POM
Source	GERMANY
Agent	IBN KHALDOON DRUG STORE
Retail Price	116.00 AED

Available as:

100mg - Tablets

Indications

Uroquad Tablets is used for: Hyperuricaemia, Uric acid nephropathy, Cancer therapy-induced hyperuricaemia, Gout, Recurrent renal stones

Adult Dose

Adult: PO Gout; Hyperuricaemia Mild: 100 mg/day PO initially; increased weekly to 200-300 mg/day Moderate to severe: 100 mg/day PO initially; increased weekly to 400-600 mg/day Prevention of hyperuricaemia associated w/ chemotherapy treatment or enzyme disorders 600-800 mg/day, starting 2-3 days before cancer treatment. Hepatic impairment: Dose reduction may be needed. Monitor liver function regularly.

Child Dose

Renal Dose

Renal impairment: Haemodialysis: Administer dose after session or administer 50% supplemental dose. CrCl (ml/min) 10-20 200 mg daily. <3 100 mg daily at extended intervals. 3-10 100 mg daily.

Administration

Administration Should be taken with food. Take immediately after meals.

Contra Indications

Hypersensitivity; acute attack of gout.

Precautions

Ensure adequate fluid intake. Prophylactically with an anti-inflammatory or colchicine for at least 1 mth. Withdraw immediately when sensitivity (skin rash, etc) appears. Pregnancy, lactation. Hepatic and renal impairment. Lactation: Agent is distributed into breast milk; use with caution.

Pregnancy-Lactation

Pregnancy Experience with human pregnancy limited partly because women of reproductive age rarely require treatment with drug; There are, however, no adequate or well controlled studies in pregnant women; because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed Lactation Allopurinol and oxipurinol have been found in milk of mother who was receiving drug; since effect of allopurinol on nursing infant is unknown, exercise caution when therapy is administered to nursing woman

Interactions

May inhibit the metabolism of mercaptopurine and azathioprine; reduce dose of mercaptopurine and azathioprine when given w/ allopurinol. May increase effect of warfarin and other coumarin anticoagulants. Increased excretion of the oxipurinol (metabolite) w/ salicylates or uricosuric agents. Increased toxicity w/ thiazide diuretics, some antibacterials, other antineoplastics, ciclosporin, some sulfonylurea antidiabetics, theophylline and vidarabine.

Adverse Effects

Side effects of Allopurinol : 1-10% Rash (1.5%), Nausea (1.3%), Renal failure (1.2%), Vomiting (1.2%) Frequency Not Defined Amblyopia, Arthralgias, Blood dyscrasias, Bronchospasm, Cardiovascular abnormalities, Cataracts, Confusion, Decrease in libido, Dizziness, Ecchymosis, Electrolyte abnormalities, Epistaxis, Foot drop, Hematuria, Hepatotoxicity, Hypotonia, Iritis, Kidney function abnormality, Macular retinitis, Malaise, Neuritis, Pharyngitis, Pruritus, Skin edema, Stevens-Johnson syndrome, Sweating, Tinnitus Potentially Fatal: Stevens-Jonhson and/or Lyell's Syndrome (urticaria, fever, lymphadenopathy, arthralgia). Occasionally, thrombocytopaenia, agranulocytosis and aplastic anaemia.

Mechanism of Action

Allopurinol is an inhibitor of the enzyme xanthine oxidase which converts hypoxanthine to xanthine then uric acid. The reduced production of uric acid relieves all symptoms associated with hyperuricaemia and gout. Inhibition of xanthine oxidase leads to accumulation of its substrates hypoxanthine and xanthine but since their renal clearance is more than 10 times that of uric acid, there is no risk of nephrolithiasis.

Note

Uroquad 300mg Tablets manufactured by BOEHRINGER MANNHEIM GmbH. Its generic name is Allopurinol. Uroquad is availble in United Arab Emirates. Farmaco UAE drug index information on Uroquad Tablets is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Allopurinol :

Oman Pharmaceutical Products

Tablets

Loric ^300mg

Oman Pharmaceutical Products

Tablets

No-Uric ^100mg

Egyptian International Pharmaceutical Industries Co. (E.I.P.I.Co.)

Tablets

No-Uric ^300mg

Egyptian International Pharmaceutical Industries Co. (E.I.P.I.Co.)