Vancomicina Azevedos Infusion

Vancomycin

500 mg / 1 Vial

LABORATORIOS AZEVEDOS- INDUSTRIA FARMACEUTICA, S.A

Pack size	1 Glass Vial
Dispensing mode	POM
Source	PORTUGAL
Agent	AL MANARAH MEDICINE STORE L.L.C.
Retail Price	26.00 AED

Available as:

1000 mg / 1 Vial - Infusion 1000 mg / 1 Vial - Infusion 500 mg / 1 Vial - Infusion

Indications

Vancomicina Azevedos Infusion is used for: Septicaemia, Soft tissue infections, Osteomyelitis, Enterocolitis, Colitis, Serious staphylococcal or other Gm +ve infections, Bacterial endocarditis

Adult Dose

Intravenous Severe staphylococcal or other Gram-positive infections, Endocarditis Adult: 500 mg 6 hrly, infused over at least 60 min or 1 g 12 hrly, infused over at least 100 min. Elderly: Dosage adjustment needed.

Child Dose

Intravenous Children Severe staphylococcal or other Gram-positive infections, Endocarditis <1 month: 15 mg/kg followed by 10 mg/kg IV q12hr for neonates in first week of life and q8hr thereafter up to 1 month of age; longer dosing intervals recommended in premature infants >1 month: 10 mg/kg/day IV divided q6hr; individual dose not to exceed 1 g

Renal Dose

Renal impairment: Patient on intermittent haemodialysis: Loading dose: 15-25 mg/kg on day 1, followed by 5-10 mg/kg maintenance dose after each dialysis run. Anuric patient (w/o kidney function) on dialysis: Initially, 15 mg/kg. Maintenance: 1.9 mg/kg 24 hrly. CrCl (ml/min) Dosage Recommendation <20 Longer intervals; determine by serum concentration monitoring. 20-49 Initially, 15-20 mg/kg/dose (usual: 750-1,500 mg) 24 hrly. >50 Initially, 15-20 mg/kg/dose (usual: 750-1,500 mg) 8-12 hrly.

Administration

IV Preparation Add 10 mL of SWI to 500-mg vial and 20 mL of SWI to 1-g vial to yield 50 mg/mL solution; further dilution is required, depending on method of administration Intermittent infusion: Dilute 500 mg with ?100 mL of diluent and 1 g with ?200 mL of diluent (NS or D5W) Continuous infusion: Dilute in sufficient amount to permit infusion over 24 hours IV Administration Intermittent (preferred): Administer over 60 minutes; not to exceed 10 mg/min Continuous: Administer over 24 hours

Contra Indications

Hypersensitivity to the drug; history of impaired hearing; IM administration.

Precautions

Patient w/ allergic reaction to teicoplanin, previous hearing loss, inflammatory bowel disease. Renal impairment. Elderly. Pregnancy and lactation. Monitoring Parameters Determine regularly serial tests of auditory function and serum or blood vancomycin concentrations during treatment. Periodic urinalysis and renal function tests. Monitor leukocyte count in prolonged therapy. Lactation: Drug enters breast milk; not recommended

Pregnancy-Lactation

Pregnancy Animal reproduction studies have not been conducted with vancomycin Unknown whether vancomycin can affect reproduction capacity In a controlled clinical study, potential ototoxic and nephrotoxic effects of vancomycin on infants were evaluated when administered to pregnant women for serious staphylococcal infections complicating IV drug abuse Single-dose flexible bags only This formulation is not recommended for use during pregnancy because it contains the excipients, PEG 400 and NADA, which caused fetal malformations in animal reproduction studies (see Contraindications) Perform a pregnancy test in females of reproductive potential prior to prescribing this formulation Lactation Vancomycin is excreted in human milk Exercise caution when vancomycin is administered to a nursing woman Because of the potential for adverse events, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother

Interactions

General anaesth may enhance the adverse effects of vancomycin. Increased risk of ototoxicity and nephrotoxicity w/ aminoglycosides, polymyxins, ciclosporin, cisplatin and loop diuretics. Increased potential of neuromuscular blockade w/ suxamethonium or vecuronium.

Adverse Effects

Side effects of Vancomycin : >10% Erythematous rash on face and upper body (red neck or red man syndrome; related to infusion rate), Hypotension accompanied by flushing 1-10% Chills, Drug fever, Eosinophilia, Rash, Reversible neutropenia, Phlebitis <1% Nephrotoxicity, Ototoxicity (especially with large doses), Stevens-Johnson syndrome, Thrombocytopenia, Vasculitis Potentially Fatal: Stevens-Johnson syndrome; toxic epidermal necrolysis, blood dyscrasias such as neutropenia or thrombocytopenia.

Mechanism of Action

Vancomycin binds tightly to D-alanyl-D-alanine portion cell wall precursor causing blockage of glycopeptide polymerisation which produces immediate inhibition of cell wall synthesis and secondary damage to the cytoplasmic membrane.

Note

Vancomicina Azevedos 500 mg / 1 Vial Infusion manufactured by LABORATORIOS AZEVEDOS- INDUSTRIA FARMACEUTICA, S.A. Its generic name is Vancomycin. Vancomicina Azevedos is availble in United Arab Emirates. Farmaco UAE drug index information on Vancomicina Azevedos Infusion is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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Powder for Solution for Injection

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