VENCLEXTA & Combi-Pack Tablets / Film-coated
Venetoclax
100mg
ABBVIE Inc.
| Pack size | 42 Tablets [4x7 days Wallet - 1st week 10mg (2'sx7)+2nd week 50mg (1'sx7)+3rd week 100mg (1'sx7)+4th week 100mg (1'sx14)] |
|---|---|
| Dispensing mode | POM |
| Source | USA |
| Agent | CITY MEDICAL STORE |
| Retail Price | 9138.00 AED |
Available as:
Indications
VENCLEXTA & Combi-Pack Tablets / Film-coated is used for:
For the treatment of patients with chronic lymphocytic leukemia (CLL) with 17p deletion, as detected by an FDA approved test, who have received at least one prior therapy.
Adult Dose
Child Dose
Renal Dose
Administration
Contra Indications
Precautions
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Venetoclax :
Mechanism of Action
Venetoclax is a selective and orally bioavailable small-molecule inhibitor of BCL-2, an anti-apoptotic protein. Overexpression of BCL-2 has been demonstrated in CLL cells where it mediates tumor cell survival and has been associated with resistance to chemotherapeutics. Venetoclax helps restore the process of apoptosis by binding directly to the BCL-2 protein, displacing pro-apoptotic proteins like BIM, triggering mitochondrial outer membrane permeabilization and the activation of caspases. In nonclinical studies, venetoclax has demonstrated cytotoxic activity in tumor cells that overexpress BCL-2.
Note
VENCLEXTA & Combi-Pack 100mg Tablets / Film-coated manufactured by ABBVIE Inc.. Its generic name is Venetoclax. VENCLEXTA & Combi-Pack is availble in United Arab Emirates.
Farmaco UAE drug index information on VENCLEXTA & Combi-Pack Tablets / Film-coated is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.